node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SFH21433.1 | SFH21459.1 | SAMN04487959_101266 | SAMN04487959_101267 | N-acetylmuramoyl-L-alanine amidase. | tRNA threonylcarbamoyladenosine biosynthesis protein TsaE. | 0.870 |
SFH21433.1 | SFH83955.1 | SAMN04487959_101266 | SAMN04487959_110123 | N-acetylmuramoyl-L-alanine amidase. | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | 0.556 |
SFH21433.1 | hflX | SAMN04487959_101266 | SAMN04487959_101262 | N-acetylmuramoyl-L-alanine amidase. | GTP-binding protein HflX; GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family. | 0.617 |
SFH21433.1 | miaA | SAMN04487959_101266 | SAMN04487959_101264 | N-acetylmuramoyl-L-alanine amidase. | tRNA dimethylallyltransferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. | 0.880 |
SFH21433.1 | mutL | SAMN04487959_101266 | SAMN04487959_101265 | N-acetylmuramoyl-L-alanine amidase. | DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | 0.879 |
SFH21433.1 | nnrE | SAMN04487959_101266 | SAMN04487959_101268 | N-acetylmuramoyl-L-alanine amidase. | NAD(P)H-hydrate epimerase; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of bot [...] | 0.926 |
SFH21459.1 | SFH21433.1 | SAMN04487959_101267 | SAMN04487959_101266 | tRNA threonylcarbamoyladenosine biosynthesis protein TsaE. | N-acetylmuramoyl-L-alanine amidase. | 0.870 |
SFH21459.1 | SFH52396.1 | SAMN04487959_101267 | SAMN04487959_10588 | tRNA threonylcarbamoyladenosine biosynthesis protein TsaE. | tRNA threonylcarbamoyl adenosine modification protein, Sua5/YciO/YrdC/YwlC family; Belongs to the SUA5 family. | 0.915 |
SFH21459.1 | SFH83955.1 | SAMN04487959_101267 | SAMN04487959_110123 | tRNA threonylcarbamoyladenosine biosynthesis protein TsaE. | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | 0.853 |
SFH21459.1 | SFH92046.1 | SAMN04487959_101267 | SAMN04487959_112106 | tRNA threonylcarbamoyladenosine biosynthesis protein TsaE. | tRNA threonylcarbamoyladenosine biosynthesis protein TsaB. | 0.998 |
SFH21459.1 | hflX | SAMN04487959_101267 | SAMN04487959_101262 | tRNA threonylcarbamoyladenosine biosynthesis protein TsaE. | GTP-binding protein HflX; GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family. | 0.751 |
SFH21459.1 | miaA | SAMN04487959_101267 | SAMN04487959_101264 | tRNA threonylcarbamoyladenosine biosynthesis protein TsaE. | tRNA dimethylallyltransferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. | 0.880 |
SFH21459.1 | mutL | SAMN04487959_101267 | SAMN04487959_101265 | tRNA threonylcarbamoyladenosine biosynthesis protein TsaE. | DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | 0.837 |
SFH21459.1 | nnrE | SAMN04487959_101267 | SAMN04487959_101268 | tRNA threonylcarbamoyladenosine biosynthesis protein TsaE. | NAD(P)H-hydrate epimerase; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of bot [...] | 0.969 |
SFH21459.1 | tsaC | SAMN04487959_101267 | SAMN04487959_102204 | tRNA threonylcarbamoyladenosine biosynthesis protein TsaE. | L-threonylcarbamoyladenylate synthase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate. | 0.903 |
SFH21459.1 | tsaD | SAMN04487959_101267 | SAMN04487959_11218 | tRNA threonylcarbamoyladenosine biosynthesis protein TsaE. | O-sialoglycoprotein endopeptidase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family. | 0.994 |
SFH52396.1 | SFH21459.1 | SAMN04487959_10588 | SAMN04487959_101267 | tRNA threonylcarbamoyl adenosine modification protein, Sua5/YciO/YrdC/YwlC family; Belongs to the SUA5 family. | tRNA threonylcarbamoyladenosine biosynthesis protein TsaE. | 0.915 |
SFH52396.1 | SFH83955.1 | SAMN04487959_10588 | SAMN04487959_110123 | tRNA threonylcarbamoyl adenosine modification protein, Sua5/YciO/YrdC/YwlC family; Belongs to the SUA5 family. | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | 0.664 |
SFH52396.1 | SFH92046.1 | SAMN04487959_10588 | SAMN04487959_112106 | tRNA threonylcarbamoyl adenosine modification protein, Sua5/YciO/YrdC/YwlC family; Belongs to the SUA5 family. | tRNA threonylcarbamoyladenosine biosynthesis protein TsaB. | 0.915 |
SFH52396.1 | tsaD | SAMN04487959_10588 | SAMN04487959_11218 | tRNA threonylcarbamoyl adenosine modification protein, Sua5/YciO/YrdC/YwlC family; Belongs to the SUA5 family. | O-sialoglycoprotein endopeptidase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family. | 0.921 |