node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SFH28189.1 | SFH53251.1 | SAMN04487959_102101 | SAMN04487959_105132 | Tartrate dehydrogenase/decarboxylase / D-malate dehydrogenase. | Glutamate synthase (NADPH) large subunit. | 0.936 |
SFH28189.1 | SFH70567.1 | SAMN04487959_102101 | SAMN04487959_10854 | Tartrate dehydrogenase/decarboxylase / D-malate dehydrogenase. | hydroxymethylglutaryl-CoA lyase. | 0.811 |
SFH28189.1 | SFH73741.1 | SAMN04487959_102101 | SAMN04487959_108215 | Tartrate dehydrogenase/decarboxylase / D-malate dehydrogenase. | Fumarase, class I, homodimeric; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | 0.850 |
SFH28189.1 | SFI09844.1 | SAMN04487959_102101 | SAMN04487959_1184 | Tartrate dehydrogenase/decarboxylase / D-malate dehydrogenase. | Acetolactate synthase, small subunit. | 0.953 |
SFH28189.1 | SFI09869.1 | SAMN04487959_102101 | SAMN04487959_1185 | Tartrate dehydrogenase/decarboxylase / D-malate dehydrogenase. | Acetolactate synthase, large subunit. | 0.840 |
SFH28189.1 | ilvC | SAMN04487959_102101 | SAMN04487959_1182 | Tartrate dehydrogenase/decarboxylase / D-malate dehydrogenase. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.849 |
SFH28189.1 | leuA | SAMN04487959_102101 | SAMN04487959_101199 | Tartrate dehydrogenase/decarboxylase / D-malate dehydrogenase. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.846 |
SFH28189.1 | leuA-2 | SAMN04487959_102101 | SAMN04487959_101278 | Tartrate dehydrogenase/decarboxylase / D-malate dehydrogenase. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.846 |
SFH28189.1 | leuC | SAMN04487959_102101 | SAMN04487959_10726 | Tartrate dehydrogenase/decarboxylase / D-malate dehydrogenase. | 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.963 |
SFH28189.1 | leuD | SAMN04487959_102101 | SAMN04487959_10727 | Tartrate dehydrogenase/decarboxylase / D-malate dehydrogenase. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.945 |
SFH53251.1 | SFH28189.1 | SAMN04487959_105132 | SAMN04487959_102101 | Glutamate synthase (NADPH) large subunit. | Tartrate dehydrogenase/decarboxylase / D-malate dehydrogenase. | 0.936 |
SFH53251.1 | SFH70567.1 | SAMN04487959_105132 | SAMN04487959_10854 | Glutamate synthase (NADPH) large subunit. | hydroxymethylglutaryl-CoA lyase. | 0.483 |
SFH53251.1 | SFH73741.1 | SAMN04487959_105132 | SAMN04487959_108215 | Glutamate synthase (NADPH) large subunit. | Fumarase, class I, homodimeric; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | 0.440 |
SFH53251.1 | SFI09844.1 | SAMN04487959_105132 | SAMN04487959_1184 | Glutamate synthase (NADPH) large subunit. | Acetolactate synthase, small subunit. | 0.737 |
SFH53251.1 | SFI09869.1 | SAMN04487959_105132 | SAMN04487959_1185 | Glutamate synthase (NADPH) large subunit. | Acetolactate synthase, large subunit. | 0.596 |
SFH53251.1 | ilvC | SAMN04487959_105132 | SAMN04487959_1182 | Glutamate synthase (NADPH) large subunit. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.871 |
SFH53251.1 | leuA | SAMN04487959_105132 | SAMN04487959_101199 | Glutamate synthase (NADPH) large subunit. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.483 |
SFH53251.1 | leuA-2 | SAMN04487959_105132 | SAMN04487959_101278 | Glutamate synthase (NADPH) large subunit. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.483 |
SFH53251.1 | leuC | SAMN04487959_105132 | SAMN04487959_10726 | Glutamate synthase (NADPH) large subunit. | 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.795 |
SFH53251.1 | leuD | SAMN04487959_105132 | SAMN04487959_10727 | Glutamate synthase (NADPH) large subunit. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.666 |