node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SFH16502.1 | SFH17687.1 | SAMN04487959_10139 | SAMN04487959_10197 | uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | uroporphyrin-III C-methyltransferase. | 0.983 |
SFH16502.1 | SFI05007.1 | SAMN04487959_10139 | SAMN04487959_115120 | uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | Hypothetical protein. | 0.497 |
SFH17687.1 | SFH16502.1 | SAMN04487959_10197 | SAMN04487959_10139 | uroporphyrin-III C-methyltransferase. | uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | 0.983 |
SFH17687.1 | SFI05007.1 | SAMN04487959_10197 | SAMN04487959_115120 | uroporphyrin-III C-methyltransferase. | Hypothetical protein. | 0.447 |
SFH22591.1 | SFH22616.1 | SAMN04487959_101321 | SAMN04487959_101322 | ProP effector; RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities; Belongs to the ProQ family. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.806 |
SFH22591.1 | SFH22678.1 | SAMN04487959_101321 | SAMN04487959_101325 | ProP effector; RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities; Belongs to the ProQ family. | CheY chemotaxis protein or a CheY-like REC (receiver) domain. | 0.471 |
SFH22591.1 | SFI05007.1 | SAMN04487959_101321 | SAMN04487959_115120 | ProP effector; RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities; Belongs to the ProQ family. | Hypothetical protein. | 0.459 |
SFH22591.1 | thyA | SAMN04487959_101321 | SAMN04487959_101323 | ProP effector; RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities; Belongs to the ProQ family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.806 |
SFH22616.1 | SFH22591.1 | SAMN04487959_101322 | SAMN04487959_101321 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | ProP effector; RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities; Belongs to the ProQ family. | 0.806 |
SFH22616.1 | SFH22678.1 | SAMN04487959_101322 | SAMN04487959_101325 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | CheY chemotaxis protein or a CheY-like REC (receiver) domain. | 0.638 |
SFH22616.1 | SFH22696.1 | SAMN04487959_101322 | SAMN04487959_101326 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Uncharacterized conserved protein, contains NRDE domain. | 0.511 |
SFH22616.1 | SFI05007.1 | SAMN04487959_101322 | SAMN04487959_115120 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Hypothetical protein. | 0.556 |
SFH22616.1 | thyA | SAMN04487959_101322 | SAMN04487959_101323 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.999 |
SFH22678.1 | SFH22591.1 | SAMN04487959_101325 | SAMN04487959_101321 | CheY chemotaxis protein or a CheY-like REC (receiver) domain. | ProP effector; RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities; Belongs to the ProQ family. | 0.471 |
SFH22678.1 | SFH22616.1 | SAMN04487959_101325 | SAMN04487959_101322 | CheY chemotaxis protein or a CheY-like REC (receiver) domain. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.638 |
SFH22678.1 | SFH22696.1 | SAMN04487959_101325 | SAMN04487959_101326 | CheY chemotaxis protein or a CheY-like REC (receiver) domain. | Uncharacterized conserved protein, contains NRDE domain. | 0.729 |
SFH22678.1 | SFI05007.1 | SAMN04487959_101325 | SAMN04487959_115120 | CheY chemotaxis protein or a CheY-like REC (receiver) domain. | Hypothetical protein. | 0.487 |
SFH22678.1 | thyA | SAMN04487959_101325 | SAMN04487959_101323 | CheY chemotaxis protein or a CheY-like REC (receiver) domain. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.638 |
SFH22696.1 | SFH22616.1 | SAMN04487959_101326 | SAMN04487959_101322 | Uncharacterized conserved protein, contains NRDE domain. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.511 |
SFH22696.1 | SFH22678.1 | SAMN04487959_101326 | SAMN04487959_101325 | Uncharacterized conserved protein, contains NRDE domain. | CheY chemotaxis protein or a CheY-like REC (receiver) domain. | 0.729 |