STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cobB-2NAD-dependent protein deacetylase, SIR2 family; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form; Belongs to the sirtuin family. Class II subfamily. (290 aa)    
Predicted Functional Partners:
SFH73692.1
Bifunctional NMN adenylyltransferase/nudix hydrolase.
  
 
 0.932
SFH18485.1
Glutamate dehydrogenase (NADP+); Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
    
 0.927
dnaK
Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
    
 0.918
SFI22855.1
Fatty-acid peroxygenase.
    
  0.905
SFH78116.1
Quinol:cytochrome c oxidoreductase pentaheme cytochrome subunit.
     
 0.884
SFH43551.1
Curved DNA-binding protein.
   
  0.878
dnaJ
Molecular chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, [...]
   
  0.878
SFH83146.1
DnaJ like chaperone protein.
   
  0.878
SFH48003.1
Hypothetical protein.
   
  0.877
SFH73194.1
Superoxide dismutase, Fe-Mn family; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family.
    
 0.852
Your Current Organism:
Halomonas xianhensis
NCBI taxonomy Id: 442341
Other names: CGMCC 1.6848, H. xianhensis, Halomonas sp. A-1, Halomonas xianhensis Zhao et al. 2012, JCM 14849, strain A-1
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