STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
unguracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. (239 aa)    
Predicted Functional Partners:
BLA_0718
Possible exodeoxyribonuclease; COG0708: Exonuclease III.
  
 0.796
dnaN
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
   
 
 0.657
nth
Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.
  
 
 0.638
BLA_1180
COG0714: MoxR-like ATPases.
     
 0.602
trpD
Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA).
      0.595
BLA_1173
Conserved hypothetical protein.
       0.595
BLA_1179
COG1721: Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain).
       0.593
BLA_1177
Von Willebrand factor, type A; COG2304: Uncharacterized protein containing a von Willebrand factor type A (vWA) domain.
       0.592
BLA_1176
COG2304: Uncharacterized protein containing a von Willebrand factor type A (vWA) domain.
       0.591
BLA_1178
Conserved hypothetical protein.
       0.590
Your Current Organism:
Bifidobacterium animalis
NCBI taxonomy Id: 442563
Other names: B. animalis subsp. lactis AD011, Bifidobacterium animalis subsp. lactis AD011, Bifidobacterium animalis subsp. lactis str. AD011, Bifidobacterium animalis subsp. lactis strain AD011, Bifidobacterium lactis AD011
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