STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sucCsuccinyl-CoA synthetase beta chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (397 aa)    
Predicted Functional Partners:
sucD
succinyl-CoA ligase; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
 0.999
sdhA
COG1053: Succinate dehydrogenase/fumarate reductase, flavoprotein subunit.
 
 0.988
BLA_0979
Probable iron sulfur protein associated with succinate dehydrogenase/fumarate reductase; COG0479: Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit.
 
 0.986
gltA
COG0372: Citrate synthase; Belongs to the citrate synthase family.
  
 
 0.965
adh-2
Putative alcohol dehydrogenase; COG1012: NAD-dependent aldehyde dehydrogenases; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.
  
 0.914
leuA
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
  
 0.843
BLA_0132
Biotin carboxylase/biotin carboxyl carrier protein; COG4770: Acetyl/propionyl-CoA carboxylase, alpha subunit.
   
 0.836
jadJ
JadJ; COG4770: Acetyl/propionyl-CoA carboxylase, alpha subunit.
   
 0.836
pta
Phosphate acetyltransferase; COG0280: Phosphotransacetylase.
  
 
 0.835
BLA_1290
Isocitrate dehydrogenase, NADP-dependent; COG0538: Isocitrate dehydrogenases; Belongs to the isocitrate and isopropylmalate dehydrogenases family.
  
  
 0.815
Your Current Organism:
Bifidobacterium animalis
NCBI taxonomy Id: 442563
Other names: B. animalis subsp. lactis AD011, Bifidobacterium animalis subsp. lactis AD011, Bifidobacterium animalis subsp. lactis str. AD011, Bifidobacterium animalis subsp. lactis strain AD011, Bifidobacterium lactis AD011
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