node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GM18_0544 | GM18_0546 | GM18_0544 | GM18_0546 | PFAM: Precorrin-8X methylmutase CbiC/CobH; KEGG: gem:GM21_3611 precorrin-8X methylmutase CbiC/CobH. | TIGRFAM: precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit; precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; KEGG: gem:GM21_3609 precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; protein-L-isoaspartate(D-aspartate) O-methyltransferase. | 0.999 |
GM18_0544 | GM18_0547 | GM18_0544 | GM18_0547 | PFAM: Precorrin-8X methylmutase CbiC/CobH; KEGG: gem:GM21_3611 precorrin-8X methylmutase CbiC/CobH. | TIGRFAM: precorrin-2 C20-methyltransferase; KEGG: gem:GM21_3608 precorrin-2 C20-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Belongs to the precorrin methyltransferase family. | 0.986 |
GM18_0544 | GM18_0548 | GM18_0544 | GM18_0548 | PFAM: Precorrin-8X methylmutase CbiC/CobH; KEGG: gem:GM21_3611 precorrin-8X methylmutase CbiC/CobH. | TIGRFAM: precorrin-4 C11-methyltransferase; KEGG: gbm:Gbem_3541 precorrin-4 C11-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Belongs to the precorrin methyltransferase family. | 0.988 |
GM18_0544 | GM18_0549 | GM18_0544 | GM18_0549 | PFAM: Precorrin-8X methylmutase CbiC/CobH; KEGG: gem:GM21_3611 precorrin-8X methylmutase CbiC/CobH. | PFAM: cobalamin (vitamin B12) biosynthesis CbiG protein; Cobalamin synthesis G-like; Cobalamin biosynthesis central region; KEGG: gem:GM21_3606 cobalamin (vitamin B12) biosynthesis CbiG protein. | 0.975 |
GM18_0544 | GM18_0552 | GM18_0544 | GM18_0552 | PFAM: Precorrin-8X methylmutase CbiC/CobH; KEGG: gem:GM21_3611 precorrin-8X methylmutase CbiC/CobH. | KEGG: gem:GM21_3603 L-threonine-O-3-phosphate decarboxylase; TIGRFAM: L-threonine-O-3-phosphate decarboxylase; PFAM: aminotransferase class I and II. | 0.876 |
GM18_0544 | cbiA | GM18_0544 | GM18_4240 | PFAM: Precorrin-8X methylmutase CbiC/CobH; KEGG: gem:GM21_3611 precorrin-8X methylmutase CbiC/CobH. | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | 0.997 |
GM18_0544 | cbiD | GM18_0544 | GM18_0545 | PFAM: Precorrin-8X methylmutase CbiC/CobH; KEGG: gem:GM21_3611 precorrin-8X methylmutase CbiC/CobH. | Cobalamin biosynthesis protein CbiD; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. | 0.985 |
GM18_0544 | cbiM | GM18_0544 | GM18_4238 | PFAM: Precorrin-8X methylmutase CbiC/CobH; KEGG: gem:GM21_3611 precorrin-8X methylmutase CbiC/CobH. | Cobalamin biosynthesis protein CbiM; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. | 0.735 |
GM18_0544 | cobD | GM18_0544 | GM18_0551 | PFAM: Precorrin-8X methylmutase CbiC/CobH; KEGG: gem:GM21_3611 precorrin-8X methylmutase CbiC/CobH. | Cobalamin biosynthesis protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | 0.934 |
GM18_0544 | cobQ | GM18_0544 | GM18_0550 | PFAM: Precorrin-8X methylmutase CbiC/CobH; KEGG: gem:GM21_3611 precorrin-8X methylmutase CbiC/CobH. | Cobyric acid synthase CobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.996 |
GM18_0546 | GM18_0544 | GM18_0546 | GM18_0544 | TIGRFAM: precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit; precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; KEGG: gem:GM21_3609 precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; protein-L-isoaspartate(D-aspartate) O-methyltransferase. | PFAM: Precorrin-8X methylmutase CbiC/CobH; KEGG: gem:GM21_3611 precorrin-8X methylmutase CbiC/CobH. | 0.999 |
GM18_0546 | GM18_0547 | GM18_0546 | GM18_0547 | TIGRFAM: precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit; precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; KEGG: gem:GM21_3609 precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; protein-L-isoaspartate(D-aspartate) O-methyltransferase. | TIGRFAM: precorrin-2 C20-methyltransferase; KEGG: gem:GM21_3608 precorrin-2 C20-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Belongs to the precorrin methyltransferase family. | 0.996 |
GM18_0546 | GM18_0548 | GM18_0546 | GM18_0548 | TIGRFAM: precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit; precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; KEGG: gem:GM21_3609 precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; protein-L-isoaspartate(D-aspartate) O-methyltransferase. | TIGRFAM: precorrin-4 C11-methyltransferase; KEGG: gbm:Gbem_3541 precorrin-4 C11-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Belongs to the precorrin methyltransferase family. | 0.998 |
GM18_0546 | GM18_0549 | GM18_0546 | GM18_0549 | TIGRFAM: precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit; precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; KEGG: gem:GM21_3609 precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; protein-L-isoaspartate(D-aspartate) O-methyltransferase. | PFAM: cobalamin (vitamin B12) biosynthesis CbiG protein; Cobalamin synthesis G-like; Cobalamin biosynthesis central region; KEGG: gem:GM21_3606 cobalamin (vitamin B12) biosynthesis CbiG protein. | 0.990 |
GM18_0546 | GM18_0552 | GM18_0546 | GM18_0552 | TIGRFAM: precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit; precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; KEGG: gem:GM21_3609 precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; protein-L-isoaspartate(D-aspartate) O-methyltransferase. | KEGG: gem:GM21_3603 L-threonine-O-3-phosphate decarboxylase; TIGRFAM: L-threonine-O-3-phosphate decarboxylase; PFAM: aminotransferase class I and II. | 0.760 |
GM18_0546 | cbiA | GM18_0546 | GM18_4240 | TIGRFAM: precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit; precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; KEGG: gem:GM21_3609 precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; protein-L-isoaspartate(D-aspartate) O-methyltransferase. | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | 0.949 |
GM18_0546 | cbiD | GM18_0546 | GM18_0545 | TIGRFAM: precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit; precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; KEGG: gem:GM21_3609 precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; protein-L-isoaspartate(D-aspartate) O-methyltransferase. | Cobalamin biosynthesis protein CbiD; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. | 0.997 |
GM18_0546 | cbiM | GM18_0546 | GM18_4238 | TIGRFAM: precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit; precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; KEGG: gem:GM21_3609 precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; protein-L-isoaspartate(D-aspartate) O-methyltransferase. | Cobalamin biosynthesis protein CbiM; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. | 0.788 |
GM18_0546 | cobD | GM18_0546 | GM18_0551 | TIGRFAM: precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit; precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; KEGG: gem:GM21_3609 precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; protein-L-isoaspartate(D-aspartate) O-methyltransferase. | Cobalamin biosynthesis protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | 0.951 |
GM18_0546 | cobQ | GM18_0546 | GM18_0550 | TIGRFAM: precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit; precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; KEGG: gem:GM21_3609 precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; protein-L-isoaspartate(D-aspartate) O-methyltransferase. | Cobyric acid synthase CobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.960 |