STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GM18_3387KEGG: gem:GM21_0946 methylenetetrahydrofolate reductase (NAD(P)H); PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (290 aa)    
Predicted Functional Partners:
GM18_0314
PFAM: homocysteine S-methyltransferase; cobalamin B12-binding domain protein; Methionine synthase B12-binding module cap domain protein; dihydropteroate synthase DHPS; KEGG: gbm:Gbem_0277 homocysteine S-methyltransferase.
 
 
 0.997
GM18_3740
PFAM: homocysteine S-methyltransferase; methylenetetrahydrofolate reductase; KEGG: gbm:Gbem_0613 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein.
  
 
0.963
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.953
folD
Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
    
 0.930
GM18_0487
KEGG: gbm:Gbem_0395 glycine cleavage system T protein; TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel.
  
 
 0.926
metE
5- methyltetrahydropteroyltriglutamate/homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family.
 
 
 0.913
thyX
Thymidylate synthase, flavin-dependent; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
     
 0.908
metK
S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
 
  
 0.840
GM18_2009
PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; KEGG: gbm:Gbem_2219 Cys/Met metabolism pyridoxal-phosphate-dependent protein.
  
 
 0.814
GM18_2010
PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; KEGG: gbm:Gbem_2218 Cys/Met metabolism pyridoxal-phosphate-dependent protein.
  
 
 0.814
Your Current Organism:
Geobacter sp. M18
NCBI taxonomy Id: 443143
Other names: G. sp. M18
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.