node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EDM46560.1 | EDM47859.1 | MDG893_03280 | MDG893_05614 | COG2214 DnaJ-class molecular chaperone. | COG0542 ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. | 0.739 |
EDM46560.1 | dnaK | MDG893_03280 | MDG893_04157 | COG2214 DnaJ-class molecular chaperone. | Molecular chaperone; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.998 |
EDM46560.1 | groL | MDG893_03280 | MDG893_01020 | COG2214 DnaJ-class molecular chaperone. | Chaperonin GroEL (HSP60 family) protein; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.906 |
EDM46560.1 | grpE | MDG893_03280 | MDG893_04162 | COG2214 DnaJ-class molecular chaperone. | Molecular chaperone GrpE (heat shock protein); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. [...] | 0.960 |
EDM46560.1 | htpG | MDG893_03280 | MDG893_08766 | COG2214 DnaJ-class molecular chaperone. | Molecular chaperone, HSP90 family protein; Molecular chaperone. Has ATPase activity. | 0.983 |
EDM46560.1 | rapA | MDG893_03280 | MDG893_20039 | COG2214 DnaJ-class molecular chaperone. | ATP-dependent helicase HepA; Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair; Belongs to the SNF2/RAD54 helicase family. RapA subfamily. | 0.725 |
EDM46560.1 | rplP | MDG893_03280 | MDG893_13779 | COG2214 DnaJ-class molecular chaperone. | 50S ribosomal protein L16; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family. | 0.778 |
EDM47821.1 | EDM47859.1 | MDG893_05424 | MDG893_05614 | Hypothetical protein; COG2214 DnaJ-class molecular chaperone. | COG0542 ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. | 0.718 |
EDM47821.1 | dnaK | MDG893_05424 | MDG893_04157 | Hypothetical protein; COG2214 DnaJ-class molecular chaperone. | Molecular chaperone; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.995 |
EDM47821.1 | groL | MDG893_05424 | MDG893_01020 | Hypothetical protein; COG2214 DnaJ-class molecular chaperone. | Chaperonin GroEL (HSP60 family) protein; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.881 |
EDM47821.1 | grpE | MDG893_05424 | MDG893_04162 | Hypothetical protein; COG2214 DnaJ-class molecular chaperone. | Molecular chaperone GrpE (heat shock protein); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. [...] | 0.914 |
EDM47821.1 | htpG | MDG893_05424 | MDG893_08766 | Hypothetical protein; COG2214 DnaJ-class molecular chaperone. | Molecular chaperone, HSP90 family protein; Molecular chaperone. Has ATPase activity. | 0.983 |
EDM47821.1 | rapA | MDG893_05424 | MDG893_20039 | Hypothetical protein; COG2214 DnaJ-class molecular chaperone. | ATP-dependent helicase HepA; Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair; Belongs to the SNF2/RAD54 helicase family. RapA subfamily. | 0.725 |
EDM47821.1 | rplP | MDG893_05424 | MDG893_13779 | Hypothetical protein; COG2214 DnaJ-class molecular chaperone. | 50S ribosomal protein L16; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family. | 0.778 |
EDM47859.1 | EDM46560.1 | MDG893_05614 | MDG893_03280 | COG0542 ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. | COG2214 DnaJ-class molecular chaperone. | 0.739 |
EDM47859.1 | EDM47821.1 | MDG893_05614 | MDG893_05424 | COG0542 ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. | Hypothetical protein; COG2214 DnaJ-class molecular chaperone. | 0.718 |
EDM47859.1 | EDM48838.1 | MDG893_05614 | MDG893_02725 | COG0542 ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. | Heat shock protein DnaJ-like protein; COG2214 DnaJ-class molecular chaperone. | 0.718 |
EDM47859.1 | dnaJ | MDG893_05614 | MDG893_04152 | COG0542 ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. | DnaJ-class molecular chaperone with C-terminal Zn finger domain; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of A [...] | 0.763 |
EDM47859.1 | dnaK | MDG893_05614 | MDG893_04157 | COG0542 ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. | Molecular chaperone; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.980 |
EDM47859.1 | groL | MDG893_05614 | MDG893_01020 | COG0542 ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. | Chaperonin GroEL (HSP60 family) protein; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.658 |