node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EDM46827.1 | EDM47937.1 | MDG893_17642 | MDG893_15145 | Ankyrin-related protein; COG0666 FOG: Ankyrin repeat. | Class II aldolase/adducin, N-terminal family protein; Putative enzyme; COG0235 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases. | 0.585 |
EDM46827.1 | EDM49073.1 | MDG893_17642 | MDG893_06745 | Ankyrin-related protein; COG0666 FOG: Ankyrin repeat. | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.772 |
EDM46827.1 | mtnB | MDG893_17642 | MDG893_09461 | Ankyrin-related protein; COG0666 FOG: Ankyrin repeat. | Ribulose-5-phosphate 4-epimerase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Belongs to the aldolase class II family. MtnB subfamily. | 0.585 |
EDM47568.1 | EDM47937.1 | MDG893_00502 | MDG893_15145 | Methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. | Class II aldolase/adducin, N-terminal family protein; Putative enzyme; COG0235 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases. | 0.535 |
EDM47568.1 | mtnA | MDG893_00502 | MDG893_09686 | Methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. | Putative initiation factor 2 subunit; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). | 0.978 |
EDM47568.1 | mtnB | MDG893_00502 | MDG893_09461 | Methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. | Ribulose-5-phosphate 4-epimerase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Belongs to the aldolase class II family. MtnB subfamily. | 0.587 |
EDM47568.1 | mtnD | MDG893_00502 | MDG893_09456 | Methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. | Uncharacterized conserved protein, contains double-stranded beta-helix domain; Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. | 0.524 |
EDM47568.1 | speE | MDG893_00502 | MDG893_14590 | Methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. | Spermidine synthase; Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine. | 0.623 |
EDM47617.1 | EDM47937.1 | MDG893_19619 | MDG893_15145 | COG0666 FOG: Ankyrin repeat. | Class II aldolase/adducin, N-terminal family protein; Putative enzyme; COG0235 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases. | 0.585 |
EDM47617.1 | EDM49073.1 | MDG893_19619 | MDG893_06745 | COG0666 FOG: Ankyrin repeat. | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.772 |
EDM47617.1 | mtnB | MDG893_19619 | MDG893_09461 | COG0666 FOG: Ankyrin repeat. | Ribulose-5-phosphate 4-epimerase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Belongs to the aldolase class II family. MtnB subfamily. | 0.585 |
EDM47937.1 | EDM46827.1 | MDG893_15145 | MDG893_17642 | Class II aldolase/adducin, N-terminal family protein; Putative enzyme; COG0235 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases. | Ankyrin-related protein; COG0666 FOG: Ankyrin repeat. | 0.585 |
EDM47937.1 | EDM47568.1 | MDG893_15145 | MDG893_00502 | Class II aldolase/adducin, N-terminal family protein; Putative enzyme; COG0235 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases. | Methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. | 0.535 |
EDM47937.1 | EDM47617.1 | MDG893_15145 | MDG893_19619 | Class II aldolase/adducin, N-terminal family protein; Putative enzyme; COG0235 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases. | COG0666 FOG: Ankyrin repeat. | 0.585 |
EDM47937.1 | EDM49073.1 | MDG893_15145 | MDG893_06745 | Class II aldolase/adducin, N-terminal family protein; Putative enzyme; COG0235 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases. | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.630 |
EDM47937.1 | EDM49252.1 | MDG893_15145 | MDG893_07640 | Class II aldolase/adducin, N-terminal family protein; Putative enzyme; COG0235 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases. | COG1070 Sugar (pentulose and hexulose) kinases. | 0.663 |
EDM47937.1 | mtnA | MDG893_15145 | MDG893_09686 | Class II aldolase/adducin, N-terminal family protein; Putative enzyme; COG0235 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases. | Putative initiation factor 2 subunit; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). | 0.843 |
EDM47937.1 | mtnB | MDG893_15145 | MDG893_09461 | Class II aldolase/adducin, N-terminal family protein; Putative enzyme; COG0235 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases. | Ribulose-5-phosphate 4-epimerase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Belongs to the aldolase class II family. MtnB subfamily. | 0.577 |
EDM47937.1 | mtnC | MDG893_15145 | MDG893_09451 | Class II aldolase/adducin, N-terminal family protein; Putative enzyme; COG0235 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases. | 2,3-diketo-5-methylthio-1-phosphopentane phosphatase; Bifunctional enzyme that catalyzes the enolization of 2,3- diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK- MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family. | 0.593 |
EDM47937.1 | mtnD | MDG893_15145 | MDG893_09456 | Class II aldolase/adducin, N-terminal family protein; Putative enzyme; COG0235 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases. | Uncharacterized conserved protein, contains double-stranded beta-helix domain; Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. | 0.779 |