node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EDM47622.1 | EDM49833.1 | MDG893_19644 | MDG893_11546 | COG0123 Deacetylases, including yeast histone deacetylase and acetoin utilization protein. | D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding protein; COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 0.750 |
EDM47622.1 | rplF | MDG893_19644 | MDG893_13739 | COG0123 Deacetylases, including yeast histone deacetylase and acetoin utilization protein. | 50S ribosomal protein L6; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. | 0.723 |
EDM48083.1 | EDM49832.1 | MDG893_03380 | MDG893_11541 | COG1052 Lactate dehydrogenase and related dehydrogenases; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Aminotransferase, class I and II; COG0436 Aspartate/tyrosine/aromatic aminotransferase. | 0.462 |
EDM48083.1 | EDM49833.1 | MDG893_03380 | MDG893_11546 | COG1052 Lactate dehydrogenase and related dehydrogenases; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding protein; COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 0.729 |
EDM48083.1 | ilvA | MDG893_03380 | MDG893_04609 | COG1052 Lactate dehydrogenase and related dehydrogenases; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Threonine ammonia-lyase, biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.507 |
EDM48083.1 | serC | MDG893_03380 | MDG893_08940 | COG1052 Lactate dehydrogenase and related dehydrogenases; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. | 0.408 |
EDM48540.1 | EDM49833.1 | MDG893_18397 | MDG893_11546 | COG0123 Deacetylases, including yeast histone deacetylase and acetoin utilization protein. | D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding protein; COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 0.709 |
EDM48540.1 | rplF | MDG893_18397 | MDG893_13739 | COG0123 Deacetylases, including yeast histone deacetylase and acetoin utilization protein. | 50S ribosomal protein L6; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. | 0.723 |
EDM49471.1 | EDM49833.1 | MDG893_09736 | MDG893_11546 | COG0123 Deacetylases, including yeast histone deacetylase and acetoin utilization protein. | D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding protein; COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 0.709 |
EDM49471.1 | rplF | MDG893_09736 | MDG893_13739 | COG0123 Deacetylases, including yeast histone deacetylase and acetoin utilization protein. | 50S ribosomal protein L6; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. | 0.723 |
EDM49832.1 | EDM48083.1 | MDG893_11541 | MDG893_03380 | Aminotransferase, class I and II; COG0436 Aspartate/tyrosine/aromatic aminotransferase. | COG1052 Lactate dehydrogenase and related dehydrogenases; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 0.462 |
EDM49832.1 | EDM49833.1 | MDG893_11541 | MDG893_11546 | Aminotransferase, class I and II; COG0436 Aspartate/tyrosine/aromatic aminotransferase. | D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding protein; COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 0.852 |
EDM49833.1 | EDM47622.1 | MDG893_11546 | MDG893_19644 | D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding protein; COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | COG0123 Deacetylases, including yeast histone deacetylase and acetoin utilization protein. | 0.750 |
EDM49833.1 | EDM48083.1 | MDG893_11546 | MDG893_03380 | D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding protein; COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | COG1052 Lactate dehydrogenase and related dehydrogenases; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 0.729 |
EDM49833.1 | EDM48540.1 | MDG893_11546 | MDG893_18397 | D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding protein; COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | COG0123 Deacetylases, including yeast histone deacetylase and acetoin utilization protein. | 0.709 |
EDM49833.1 | EDM49471.1 | MDG893_11546 | MDG893_09736 | D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding protein; COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | COG0123 Deacetylases, including yeast histone deacetylase and acetoin utilization protein. | 0.709 |
EDM49833.1 | EDM49832.1 | MDG893_11546 | MDG893_11541 | D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding protein; COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Aminotransferase, class I and II; COG0436 Aspartate/tyrosine/aromatic aminotransferase. | 0.852 |
EDM49833.1 | ilvA | MDG893_11546 | MDG893_04609 | D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding protein; COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Threonine ammonia-lyase, biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.715 |
EDM49833.1 | rplF | MDG893_11546 | MDG893_13739 | D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding protein; COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 50S ribosomal protein L6; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. | 0.717 |
EDM49833.1 | serC | MDG893_11546 | MDG893_08940 | D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding protein; COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. | 0.875 |