node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SDP14037.1 | SDP14074.1 | SAMN04489867_1530 | SAMN04489867_1531 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | L-amino acid N-acyltransferase YncA. | 0.606 |
SDP14037.1 | SDP14122.1 | SAMN04489867_1530 | SAMN04489867_1532 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Predicted branched-chain amino acid permease (azaleucine resistance). | 0.656 |
SDP14037.1 | SDP14160.1 | SAMN04489867_1530 | SAMN04489867_1533 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Branched-chain amino acid transport protein (AzlD). | 0.658 |
SDP14037.1 | dapA | SAMN04489867_1530 | SAMN04489867_1528 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 4-hydroxy-tetrahydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). | 0.612 |
SDP14037.1 | rnj | SAMN04489867_1530 | SAMN04489867_1527 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Ribonuclease J; An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay. | 0.630 |
SDP14037.1 | thyA | SAMN04489867_1530 | SAMN04489867_1529 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.998 |
SDP14074.1 | SDP14037.1 | SAMN04489867_1531 | SAMN04489867_1530 | L-amino acid N-acyltransferase YncA. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.606 |
SDP14074.1 | SDP14122.1 | SAMN04489867_1531 | SAMN04489867_1532 | L-amino acid N-acyltransferase YncA. | Predicted branched-chain amino acid permease (azaleucine resistance). | 0.793 |
SDP14074.1 | SDP14160.1 | SAMN04489867_1531 | SAMN04489867_1533 | L-amino acid N-acyltransferase YncA. | Branched-chain amino acid transport protein (AzlD). | 0.796 |
SDP14074.1 | dapA | SAMN04489867_1531 | SAMN04489867_1528 | L-amino acid N-acyltransferase YncA. | 4-hydroxy-tetrahydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). | 0.458 |
SDP14074.1 | rnj | SAMN04489867_1531 | SAMN04489867_1527 | L-amino acid N-acyltransferase YncA. | Ribonuclease J; An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay. | 0.523 |
SDP14074.1 | thyA | SAMN04489867_1531 | SAMN04489867_1529 | L-amino acid N-acyltransferase YncA. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.613 |
SDP14122.1 | SDP14037.1 | SAMN04489867_1532 | SAMN04489867_1530 | Predicted branched-chain amino acid permease (azaleucine resistance). | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.656 |
SDP14122.1 | SDP14074.1 | SAMN04489867_1532 | SAMN04489867_1531 | Predicted branched-chain amino acid permease (azaleucine resistance). | L-amino acid N-acyltransferase YncA. | 0.793 |
SDP14122.1 | SDP14160.1 | SAMN04489867_1532 | SAMN04489867_1533 | Predicted branched-chain amino acid permease (azaleucine resistance). | Branched-chain amino acid transport protein (AzlD). | 0.991 |
SDP14122.1 | dapA | SAMN04489867_1532 | SAMN04489867_1528 | Predicted branched-chain amino acid permease (azaleucine resistance). | 4-hydroxy-tetrahydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). | 0.441 |
SDP14122.1 | rnj | SAMN04489867_1532 | SAMN04489867_1527 | Predicted branched-chain amino acid permease (azaleucine resistance). | Ribonuclease J; An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay. | 0.474 |
SDP14122.1 | thyA | SAMN04489867_1532 | SAMN04489867_1529 | Predicted branched-chain amino acid permease (azaleucine resistance). | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.647 |
SDP14160.1 | SDP14037.1 | SAMN04489867_1533 | SAMN04489867_1530 | Branched-chain amino acid transport protein (AzlD). | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.658 |
SDP14160.1 | SDP14074.1 | SAMN04489867_1533 | SAMN04489867_1531 | Branched-chain amino acid transport protein (AzlD). | L-amino acid N-acyltransferase YncA. | 0.796 |