STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEX85472.1Putative domain HDIG-containing protein; PFAM: HD domain; OB-fold nucleic acid binding domain; TIGRFAM: uncharacterized domain HDIG. (346 aa)    
Predicted Functional Partners:
topA
DNA topoisomerase I, bacterial; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removi [...]
  
    0.825
ddl
D-alanine--D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family.
       0.797
AEX85471.1
Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family.
       0.785
tmk
Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family.
    
 0.637
AEX85475.1
Histone acetyltransferase; PFAM: Radical SAM superfamily.
       0.590
AEX85470.1
PFAM: Uncharacterized protein family UPF0029; Domain of unknown function (DUF1949); TIGRFAM: uncharacterized protein, YigZ family.
       0.583
AEX84650.1
tRNA nucleotidyltransferase/poly(A) polymerase; PFAM: CBS domain; Poly A polymerase head domain; Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.
 
     0.439
AEX85479.1
Parvulin-like peptidyl-prolyl isomerase; PFAM: Fibronectin-binding protein (FBP); PPIC-type PPIASE domain.
     
 0.426
AEX85469.1
PFAM: Tellurite resistance protein TehB.
       0.410
AEX85476.1
Alcohol dehydrogenase, class IV; PFAM: Iron-containing alcohol dehydrogenase.
       0.407
Your Current Organism:
Marinitoga piezophila
NCBI taxonomy Id: 443254
Other names: M. piezophila KA3, Marinitoga piezophila KA3, Marinitoga piezophila str. KA3, Marinitoga piezophila strain KA3, Thermotogales sp. KA3
Server load: low (26%) [HD]