Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Tneu_0280paREP1; KEGG: pis:Pisl_1373 paREP1. (273 aa)    
Predicted Functional Partners:
cobD
Cobalamin biosynthesis protein CbiB; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
 
  
  0.956
cobS
Cobalamin 5'-phosphate synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family.
 
  
  0.940
Tneu_0302
PFAM: protein of unknown function DUF105; KEGG: pis:Pisl_1367 protein of unknown function DUF64.
 
     0.856
Tneu_0281
PFAM: ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; KEGG: pis:Pisl_1372 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP.
       0.685
Tneu_0295
PFAM: Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase; KEGG: pis:Pisl_1368 hypothetical protein; Belongs to the UPF0284 family.
 
     0.580
Tneu_0290
PFAM: aminotransferase class I and II; KEGG: pis:Pisl_1369 aminotransferase, class I and II.
 
     0.577
tfe
Transcription factor TFIIE, alpha subunit; Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongatio [...]
  
     0.575
Tneu_1340
KEGG: pis:Pisl_0945 iron-sulfur cluster loop.
  
     0.542
Tneu_1005
PFAM: metallophosphoesterase; KEGG: pis:Pisl_0073 metallophosphoesterase.
 
     0.541
Tneu_1286
PFAM: protein of unknown function DUF1614; KEGG: pis:Pisl_1832 protein of unknown function DUF1614.
       0.505
Your Current Organism:
Pyrobaculum neutrophilum
NCBI taxonomy Id: 444157
Other names: P. neutrophilum V24Sta, Pyrobaculum neutrophilum JCM 9278, Pyrobaculum neutrophilum V24Sta, Pyrobaculum neutrophilum str. V24Sta, Pyrobaculum neutrophilum strain V24Sta, Thermoproteus neutrophilus V24Sta
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