STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Tneu_0684KEGG: pas:Pars_1986 adenylate kinase, conjectural. (170 aa)    
Predicted Functional Partners:
Tneu_0685
PFAM: Protein of unknown function DUF54; KEGG: pai:PAE1632 hypothetical protein; Belongs to the UPF0201 family.
 
    0.876
aroD
3-dehydroquinate dehydratase, type I; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family.
     
 0.788
Tneu_0682
Transcriptional regulator, XRE family; PFAM: helix-turn-helix domain protein; KEGG: pis:Pisl_1655 transcriptional regulator, XRE family.
 
     0.773
trm1
tRNA (guanine-N(2)-)-methyltransferase; Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups; Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
       0.760
rnhB
Ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family.
 
    0.730
guaA
GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP.
   
 
 0.685
Tneu_0681
PFAM: PUA domain containing protein; KEGG: pis:Pisl_1654 PUA domain containing protein.
 
     0.659
Tneu_0668
PFAM: peptidase A24A prepilin type IV; KEGG: pis:Pisl_1644 peptidase A24A, prepilin type IV.
  
  
 0.655
Tneu_0093
DNA-(apurinic or apyrimidinic site) lyase; KEGG: pis:Pisl_1140 HhH-GPD family protein; PFAM: HhH-GPD family protein; SMART: iron-sulfur cluster loop.
  
    0.612
thiI
Thiamine biosynthesis/tRNA modification protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
       0.598
Your Current Organism:
Pyrobaculum neutrophilum
NCBI taxonomy Id: 444157
Other names: P. neutrophilum V24Sta, Pyrobaculum neutrophilum JCM 9278, Pyrobaculum neutrophilum V24Sta, Pyrobaculum neutrophilum str. V24Sta, Pyrobaculum neutrophilum strain V24Sta, Thermoproteus neutrophilus V24Sta
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