STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Tneu_0779PFAM: amino acid permease-associated region; KEGG: pas:Pars_0608 amino acid permease-associated region. (427 aa)    
Predicted Functional Partners:
aroD
3-dehydroquinate dehydratase, type I; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family.
  
 
 0.797
Tneu_0056
PFAM: protein kinase; SMART: tyrosine protein kinase; serine/threonine protein kinase; KEGG: pis:Pisl_1102 serine/threonine protein kinase.
   
 0.755
guaA
GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP.
     
 0.733
aroC
Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
  
 
 0.667
aroE
Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
  
 
 0.658
Tneu_0782
PFAM: NADP oxidoreductase coenzyme F420-dependent; KEGG: pai:PAE1917 pyrroline-5-carboxylate reductase.
   
 
 0.502
trpF
PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); KEGG: pis:Pisl_1918 phosphoribosylanthranilate isomerase; Belongs to the TrpF family.
 
 
 
 0.470
Tneu_1075
PFAM: General substrate transporter; major facilitator superfamily MFS_1; KEGG: pis:Pisl_1973 major facilitator superfamily MFS_1.
 
 
 0.466
Tneu_1992
PFAM: peptidase S8 and S53 subtilisin kexin sedolisin; KEGG: pis:Pisl_0674 peptidase S8 and S53, subtilisin, kexin, sedolisin; Belongs to the peptidase S8 family.
 
 
 0.449
Tneu_0333
PFAM: natural resistance-associated macrophage protein; KEGG: pcl:Pcal_1197 natural resistance-associated macrophage protein.
 
   
 0.410
Your Current Organism:
Pyrobaculum neutrophilum
NCBI taxonomy Id: 444157
Other names: P. neutrophilum V24Sta, Pyrobaculum neutrophilum JCM 9278, Pyrobaculum neutrophilum V24Sta, Pyrobaculum neutrophilum str. V24Sta, Pyrobaculum neutrophilum strain V24Sta, Thermoproteus neutrophilus V24Sta
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