Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Tneu_0835Alanine--glyoxylate transaminase; PFAM: aminotransferase class V; KEGG: pcl:Pcal_1612 serine--glyoxylate transaminase. (384 aa)    
Predicted Functional Partners:
fni
Isopentenyl-diphosphate delta-isomerase, type 2; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
  
 0.796
Tneu_0836
KEGG: pis:Pisl_0982 hypothetical protein.
       0.788
Tneu_0834
PFAM: HEPN domain protein; KEGG: pas:Pars_1869 HEPN domain protein.
       0.773
Tneu_0837
Conserved hypothetical protein; KEGG: pai:PAE3452 conserved within P.aerophilum.
       0.761
alaS
alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
  
  
 0.693
Tneu_1907
KEGG: pis:Pisl_0106 phosphoribosylamine--glycine ligase; TIGRFAM: phosphoribosylamine--glycine ligase; PFAM: phosphoribosylglycinamide synthetase.
  
  
 0.693
eno
Phosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family.
 
  
 0.630
Tneu_1543
PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: pis:Pisl_0554 acetolactate synthase, large subunit, biosynthetic type.
  
 
 0.628
Tneu_1468
PFAM: Threonyl/alanyl tRNA synthetase SAD; KEGG: pis:Pisl_1034 threonyl/alanyl tRNA synthetase, SAD.
  
  
 0.597
rpl40e
PFAM: Ribosomal protein L40e; KEGG: pis:Pisl_0479 50S ribosomal protein L40e; Belongs to the eukaryotic ribosomal protein eL40 family.
   
 
  0.581
Your Current Organism:
Pyrobaculum neutrophilum
NCBI taxonomy Id: 444157
Other names: P. neutrophilum V24Sta, Pyrobaculum neutrophilum JCM 9278, Pyrobaculum neutrophilum V24Sta, Pyrobaculum neutrophilum str. V24Sta, Pyrobaculum neutrophilum strain V24Sta, Thermoproteus neutrophilus V24Sta
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