Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
hemLTIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; PFAM: aminotransferase class-III; KEGG: pis:Pisl_0114 glutamate-1-semialdehyde-2,1-aminomutase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily. (424 aa)    
Predicted Functional Partners:
hemA
glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
 
 0.995
Tneu_0957
Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: pis:Pisl_0042 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.
 
 
 0.994
hemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
 
  
 0.932
Tneu_1898
PFAM: Uroporphyrinogen III synthase HEM4; KEGG: pis:Pisl_0116 uroporphyrinogen III synthase HEM4.
  
  
 0.890
Tneu_1899
TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: pis:Pisl_0115 uroporphyrin-III C-methyltransferase.
     
 0.876
Tneu_0296
PFAM: cobalamin (vitamin B12) biosynthesis CbiX protein; KEGG: pai:PAE0343 precorrin-8X methylmutase.
     
 0.866
guaA
GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP.
     
 0.854
Tneu_1901
PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; KEGG: pis:Pisl_0113 radical SAM domain protein.
  
  
 0.820
Tneu_1902
KEGG: pis:Pisl_0111 hypothetical protein.
       0.773
Tneu_1840
PFAM: aspartate/glutamate/uridylate kinase; KEGG: pis:Pisl_0273 aspartate kinase.
 
    0.635
Your Current Organism:
Pyrobaculum neutrophilum
NCBI taxonomy Id: 444157
Other names: P. neutrophilum V24Sta, Pyrobaculum neutrophilum JCM 9278, Pyrobaculum neutrophilum V24Sta, Pyrobaculum neutrophilum str. V24Sta, Pyrobaculum neutrophilum strain V24Sta, Thermoproteus neutrophilus V24Sta
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