node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Tneu_0147 | Tneu_1267 | Tneu_0147 | Tneu_1267 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: pis:Pisl_1197 adenylosuccinate lyase. | PFAM: phosphoribosyltransferase; KEGG: pis:Pisl_1854 adenine phosphoribosyltransferase. | 0.975 |
Tneu_0147 | Tneu_1907 | Tneu_0147 | Tneu_1907 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: pis:Pisl_1197 adenylosuccinate lyase. | KEGG: pis:Pisl_0106 phosphoribosylamine--glycine ligase; TIGRFAM: phosphoribosylamine--glycine ligase; PFAM: phosphoribosylglycinamide synthetase. | 0.987 |
Tneu_0147 | Tneu_1918 | Tneu_0147 | Tneu_1918 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: pis:Pisl_1197 adenylosuccinate lyase. | PFAM: IMP biosynthesis enzyme PurP domain protein; IMP biosynthesis enzyme PurP; KEGG: pis:Pisl_0095 hypothetical protein. | 0.951 |
Tneu_0147 | hisF | Tneu_0147 | Tneu_0154 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: pis:Pisl_1197 adenylosuccinate lyase. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.820 |
Tneu_0147 | hisH | Tneu_0147 | Tneu_0148 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: pis:Pisl_1197 adenylosuccinate lyase. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.958 |
Tneu_0147 | purA | Tneu_0147 | Tneu_0146 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: pis:Pisl_1197 adenylosuccinate lyase. | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.999 |
Tneu_0147 | purP | Tneu_0147 | Tneu_1919 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: pis:Pisl_1197 adenylosuccinate lyase. | IMP biosynthesis enzyme PurP domain protein; Catalyzes the ATP- and formate-dependent formylation of 5- aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates. Belongs to the phosphohexose mutase family. | 0.951 |
Tneu_0685 | Tneu_1918 | Tneu_0685 | Tneu_1918 | PFAM: Protein of unknown function DUF54; KEGG: pai:PAE1632 hypothetical protein; Belongs to the UPF0201 family. | PFAM: IMP biosynthesis enzyme PurP domain protein; IMP biosynthesis enzyme PurP; KEGG: pis:Pisl_0095 hypothetical protein. | 0.615 |
Tneu_0685 | purP | Tneu_0685 | Tneu_1919 | PFAM: Protein of unknown function DUF54; KEGG: pai:PAE1632 hypothetical protein; Belongs to the UPF0201 family. | IMP biosynthesis enzyme PurP domain protein; Catalyzes the ATP- and formate-dependent formylation of 5- aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates. Belongs to the phosphohexose mutase family. | 0.617 |
Tneu_1267 | Tneu_0147 | Tneu_1267 | Tneu_0147 | PFAM: phosphoribosyltransferase; KEGG: pis:Pisl_1854 adenine phosphoribosyltransferase. | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: pis:Pisl_1197 adenylosuccinate lyase. | 0.975 |
Tneu_1267 | Tneu_1907 | Tneu_1267 | Tneu_1907 | PFAM: phosphoribosyltransferase; KEGG: pis:Pisl_1854 adenine phosphoribosyltransferase. | KEGG: pis:Pisl_0106 phosphoribosylamine--glycine ligase; TIGRFAM: phosphoribosylamine--glycine ligase; PFAM: phosphoribosylglycinamide synthetase. | 0.624 |
Tneu_1267 | Tneu_1918 | Tneu_1267 | Tneu_1918 | PFAM: phosphoribosyltransferase; KEGG: pis:Pisl_1854 adenine phosphoribosyltransferase. | PFAM: IMP biosynthesis enzyme PurP domain protein; IMP biosynthesis enzyme PurP; KEGG: pis:Pisl_0095 hypothetical protein. | 0.900 |
Tneu_1267 | hisF | Tneu_1267 | Tneu_0154 | PFAM: phosphoribosyltransferase; KEGG: pis:Pisl_1854 adenine phosphoribosyltransferase. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.852 |
Tneu_1267 | hisH | Tneu_1267 | Tneu_0148 | PFAM: phosphoribosyltransferase; KEGG: pis:Pisl_1854 adenine phosphoribosyltransferase. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.813 |
Tneu_1267 | purA | Tneu_1267 | Tneu_0146 | PFAM: phosphoribosyltransferase; KEGG: pis:Pisl_1854 adenine phosphoribosyltransferase. | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.720 |
Tneu_1267 | purP | Tneu_1267 | Tneu_1919 | PFAM: phosphoribosyltransferase; KEGG: pis:Pisl_1854 adenine phosphoribosyltransferase. | IMP biosynthesis enzyme PurP domain protein; Catalyzes the ATP- and formate-dependent formylation of 5- aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates. Belongs to the phosphohexose mutase family. | 0.900 |
Tneu_1907 | Tneu_0147 | Tneu_1907 | Tneu_0147 | KEGG: pis:Pisl_0106 phosphoribosylamine--glycine ligase; TIGRFAM: phosphoribosylamine--glycine ligase; PFAM: phosphoribosylglycinamide synthetase. | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: pis:Pisl_1197 adenylosuccinate lyase. | 0.987 |
Tneu_1907 | Tneu_1267 | Tneu_1907 | Tneu_1267 | KEGG: pis:Pisl_0106 phosphoribosylamine--glycine ligase; TIGRFAM: phosphoribosylamine--glycine ligase; PFAM: phosphoribosylglycinamide synthetase. | PFAM: phosphoribosyltransferase; KEGG: pis:Pisl_1854 adenine phosphoribosyltransferase. | 0.624 |
Tneu_1907 | Tneu_1918 | Tneu_1907 | Tneu_1918 | KEGG: pis:Pisl_0106 phosphoribosylamine--glycine ligase; TIGRFAM: phosphoribosylamine--glycine ligase; PFAM: phosphoribosylglycinamide synthetase. | PFAM: IMP biosynthesis enzyme PurP domain protein; IMP biosynthesis enzyme PurP; KEGG: pis:Pisl_0095 hypothetical protein. | 0.490 |
Tneu_1907 | purA | Tneu_1907 | Tneu_0146 | KEGG: pis:Pisl_0106 phosphoribosylamine--glycine ligase; TIGRFAM: phosphoribosylamine--glycine ligase; PFAM: phosphoribosylglycinamide synthetase. | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.894 |