STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
ABX01063.1Protein of unknown function DUF101; Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently. (138 aa)    
Predicted Functional Partners:
rtcB
PFAM: protein of unknown function UPF0027; KEGG: mvn:Mevan_0703 protein of unknown function UPF0027; Belongs to the RtcB family.
 
 0.972
rtcA
RNA 3'-phosphate cyclase; Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
 
 
 
 0.960
ABX01061.1
PFAM: Carbamoyltransferase; KEGG: mvn:Mevan_1544 carbamoyltransferase.
       0.779
prf1
Peptide chain release factor eRF/aRF, subunit 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
  
    0.772
ABX01060.1
TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: mvn:Mevan_1543 acetolactate synthase, large subunit, biosynthetic type.
       0.521
ABX01059.1
TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: mvn:Mevan_1542 acetolactate synthase, small subunit.
       0.508
ABX02353.1
TIGRFAM: RNA methylase, NOL1/NOP2/sun family; PFAM: Fmu (Sun) domain protein; KEGG: mvn:Mevan_0449 putative RNA methylase, NOL1/NOP2/sun family; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
     
 0.473
ABX02354.1
KEGG: mvn:Mevan_0448 hypothetical protein.
       0.444
thiL
Thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family.
       0.444
ABX01101.1
2'-5' RNA ligase; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester; Belongs to the 2H phosphoesterase superfamily. ThpR family.
 
     0.436
Your Current Organism:
Methanococcus maripaludis C6
NCBI taxonomy Id: 444158
Other names: M. maripaludis C6, Methanococcus maripaludis str. C6, Methanococcus maripaludis strain C6
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