STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
trpATryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (251 aa)    
Predicted Functional Partners:
trpF
Putative tryptophan synthase, beta subunit (trpB)/anthranilate isomerase activity of trpC (trpF); The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine; Belongs to the TrpF family.
 0.999
trpC
Indole-3-glycerol phosphate synthase activity of trpC; Predicted based on similarity to Pfam PF00218 and related proteins in nr [COG0134; E]; Belongs to the TrpC family.
 
 
 0.999
trpG
Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA).
 
  
 0.996
trpD
Anthranilate synthase component II; Predicted based on similarity to Pfam PF00117 and related proteins in nr [COG0512; E].
  
  
 0.977
trpE
Anthranilate synthase component I; Predicted based on similarity to Pfam PF04715 and related proteins in nr [COG0147; E].
 
  
 0.975
ilvA
Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
  
 
 0.926
ABS30599.1
Putative phospho-2-dehydro-3-deoxyheptonate aldolase (aroG)/chorismate mutase (pheA); Predicted based on similarity to Pfam PF00793, PF01817 and related proteins in nr [COG2876, COG1605; E].
     
 0.868
lgt
Prolipoprotein diacylglyceryl transferase; Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
  
    0.867
aroC
Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
  
  
 0.768
thrA
Aspartokinase/homoserine dehydrogenase; Predicted based on similarity to Pfam PF00742, PF03447 and related proteins in nr [COG0527; E].
  
  
 0.733
Your Current Organism:
Sulcia muelleri GWSS
NCBI taxonomy Id: 444179
Other names: C. Sulcia muelleri GWSS, Candidatus Sulcia muelleri GWSS, Candidatus Sulcia muelleri str. GWSS, Candidatus Sulcia muelleri strain GWSS
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