STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AND68020.1Hypothetical protein; PRINTS: Anthranilate synthase component I signature; TIGRFAM: PabB-clade2: aminodeoxychorismate synthase, component I; Pfam: Anthranilate synthase component I, N terminal region; Pfam: chorismate binding enzyme. (450 aa)    
Predicted Functional Partners:
trpD
Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA).
 
 0.999
AND69895.1
Anthranilate synthase subunit II; PRINTS: Glutamine amidotransferase superfamily signature; Pfam: Glutamine amidotransferase class-I; PRINTS: Carbamoyl-phosphate synthase protein GATase domain signature; PRINTS: Anthranilate synthase component II signature; TIGRFAM: trpG_papA: glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase.
 0.999
trpC
Pfam: Indole-3-glycerol phosphate synthase; Belongs to the TrpC family.
 
 0.993
aroC
Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
 
 
 0.961
trpB
Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
 
  
 0.954
AND68116.1
Pfam: Prephenate dehydratase; Pfam: ACT domain; TIGRFAM: CM_P2: chorismate mutase; SMART: Chorismate mutase type II; Pfam: Chorismate mutase type II.
 
 
 0.954
trpF
Pfam: N-(5'phosphoribosyl)anthranilate (PRA) isomerase; Belongs to the TrpF family.
 
  
 0.946
trpA
Tryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.
 
  
 0.934
AND68021.1
Hypothetical protein; TIGRFAM: pabC_Proteo: aminodeoxychorismate lyase; Pfam: Aminotransferase class IV.
 
 
 0.931
trpE
Anthranilate synthase subunit I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrat [...]
  
  
 
0.918
Your Current Organism:
Dyella thiooxydans
NCBI taxonomy Id: 445710
Other names: D. thiooxydans, Dyella sp. ATSB10, Dyella thiooxydans Anandham et al. 2011, KACC 12756, LMG 24673, LMG:24673, strain ATSB10
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.