STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Emin_1305Non-canonical purine NTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (197 aa)    
Predicted Functional Partners:
guaA
GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP.
 
 
 0.960
guaB
Malate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
  
 0.931
Emin_1527
PFAM: nucleoside diphosphate kinase; KEGG: bsu:BSU22730 nucleoside diphosphate kinase; Belongs to the NDK family.
  
 0.929
Emin_1323
KEGG: drm:Dred_2376 hypoxanthine phosphoribosyltransferase; TIGRFAM: hypoxanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
  
 
 0.905
Emin_1031
PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: cff:CFF8240_1753 UshA protein; Belongs to the 5'-nucleotidase family.
  
 
  0.902
Emin_1473
PFAM: 5'-Nucleotidase domain protein; KEGG: cdf:CD2537 putative membrane-associated 5'-nucleotidase/phosphoesterase; Belongs to the 5'-nucleotidase family.
  
 
  0.902
Emin_1474
PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: fno:Fnod_0639 5'-nucleotidase domain protein; Belongs to the 5'-nucleotidase family.
  
 
  0.902
murI
Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis.
 
    0.777
proC
Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
      0.697
Emin_0413
PFAM: metallophosphoesterase; KEGG: det:DET0403 Ser/Thr protein phosphatase family protein.
  
  
 0.692
Your Current Organism:
Elusimicrobium minutum
NCBI taxonomy Id: 445932
Other names: E. minutum Pei191, Elusimicrobium minutum Pei191, Elusimicrobium minutum str. Pei191, Elusimicrobium minutum strain Pei191
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