STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tmkThymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (203 aa)    
Predicted Functional Partners:
Emin_0554
Deoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
  
 
 0.941
tdk
PFAM: thymidine kinase; KEGG: bba:Bd3420 thymidine kinase.
  
 
 0.938
Emin_1460
KEGG: afw:Anae109_2451 DNA polymerase III, delta prime subunit.
  
 0.934
Emin_1527
PFAM: nucleoside diphosphate kinase; KEGG: bsu:BSU22730 nucleoside diphosphate kinase; Belongs to the NDK family.
  
 
 0.930
Emin_1174
PFAM: CMP/dCMP deaminase zinc-binding; KEGG: abu:Abu_0039 dCMP deaminase, putative.
    
 0.921
Emin_1474
PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: fno:Fnod_0639 5'-nucleotidase domain protein; Belongs to the 5'-nucleotidase family.
 
 
  0.921
thyX
Thymidylate synthase, flavin-dependent; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
    
 0.920
Emin_1031
PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: cff:CFF8240_1753 UshA protein; Belongs to the 5'-nucleotidase family.
 
 
  0.920
Emin_1473
PFAM: 5'-Nucleotidase domain protein; KEGG: cdf:CD2537 putative membrane-associated 5'-nucleotidase/phosphoesterase; Belongs to the 5'-nucleotidase family.
 
 
  0.920
recR
Recombinational DNA repair protein; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.
    
 0.899
Your Current Organism:
Elusimicrobium minutum
NCBI taxonomy Id: 445932
Other names: E. minutum Pei191, Elusimicrobium minutum Pei191, Elusimicrobium minutum str. Pei191, Elusimicrobium minutum strain Pei191
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