STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EDS72800.1AICARFT/IMPCHase bienzyme; KEGG: hsa:471 2.6e-117 ATIC; 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase K00602:K01492; COG: COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful); Psort location: Cytoplasmic, score: 8.87. (391 aa)    
Predicted Functional Partners:
EDS71446.1
Phosphoribosylformylglycinamidine synthase; KEGG: cac:CAC1655 0. purQ, purL; bifunctional enzyme phosphoribosylformylglycinamidine (FGAM) synthase (synthetase domain/glutamine amidotransferase domain) K01952; COG: COG0046 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain.
  
 
 0.998
purN
Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
 0.995
purB
Adenylosuccinate lyase; KEGG: cpf:CPF_1922 1.4e-166 purB; adenylosuccinate lyase K01756; COG: COG0015 Adenylosuccinate lyase; Psort location: Cytoplasmic, score: 8.87.
  
 0.954
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 0.938
purA
Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
  
 0.931
purD
KEGG: pca:Pcar_2231 4.0e-112 phosphoribosylamine--glycine ligase K01945; COG: COG0151 Phosphoribosylamine-glycine ligase; Psort location: Cytoplasmic, score: 8.87; Belongs to the GARS family.
 
 0.914
purC
KEGG: cno:NT01CX_2423 4.5e-81 purC; phosphoribosylaminoimidazole-succinocarboxamide synthase K01923; COG: COG0152 Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase; Psort location: Cytoplasmic, score: 8.87; Belongs to the SAICAR synthetase family.
  
 0.909
fhs
KEGG: ngo:NGO0062 1.0e-209 putative formate--tetrahydrofolate ligase K01938; COG: COG2759 Formyltetrahydrofolate synthetase; Psort location: Cytoplasmic, score: 8.87.
  
 0.905
purF
Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
 
 0.893
hisE
phosphoribosyl-ATP diphosphatase; KEGG: bth:BT1377 3.9e-50 phosphoribosyl-AMP cyclohydrolase / phosphoribosyl-ATP pyrophosphohydrolase K01496:K01523; COG: COG0139 Phosphoribosyl-AMP cyclohydrolase; Psort location: Cytoplasmic, score: 9.65; In the N-terminal section; belongs to the PRA-CH family.
  
 
 0.885
Your Current Organism:
Anaerofustis stercorihominis
NCBI taxonomy Id: 445971
Other names: A. stercorihominis DSM 17244, Anaerofustis stercorihominis DSM 17244, Anaerofustis stercorihominis str. DSM 17244, Anaerofustis stercorihominis strain DSM 17244
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