STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
patHistidinol-phosphate aminotransferase; May catalyze the transamination reaction in phenylalanine biosynthesis; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. (355 aa)    
Predicted Functional Partners:
hisB
PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: acr:Acry_1413 imidazoleglycerol-phosphate dehydratase.
 
 0.998
hisD
Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
  
 0.985
Amir_0168
PFAM: Prephenate dehydrogenase; KEGG: gsu:GSU2607 prephenate dehydrogenase.
  
 
 0.967
pheA
PFAM: prephenate dehydratase; amino acid-binding ACT domain protein; KEGG: ank:AnaeK_2061 prephenate dehydratase.
 
 
 0.930
Amir_0878
PFAM: aminotransferase class I and II; KEGG: cko:CKO_02518 threonine-phosphate decarboxylase.
  
  
  0.920
hisC
TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; KEGG: bur:Bcep18194_C7445 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
  
  
 
0.919
Amir_0705
KEGG: bcy:Bcer98_0228 4-hydroxyphenylpyruvate dioxygenase; TIGRFAM: 4-hydroxyphenylpyruvate dioxygenase; PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase.
    
 0.910
Amir_4386
PFAM: aminotransferase class I and II; KEGG: scl:sce8915 histidinol-phosphate transaminase.
  
  
 
0.909
Amir_4353
PFAM: phenylalanine/histidine ammonia-lyase; KEGG: rsh:Rsph17029_1579 histidine ammonia-lyase.
    
 0.908
Amir_6379
TIGRFAM: histidinol-phosphate phosphatase; PFAM: inositol monophosphatase; KEGG: ade:Adeh_1287 histidinol-phosphate phosphatase.
  
 
 0.905
Your Current Organism:
Actinosynnema mirum
NCBI taxonomy Id: 446462
Other names: A. mirum DSM 43827, Actinosynnema mirum DSM 43827, Actinosynnema mirum str. DSM 43827, Actinosynnema mirum strain DSM 43827
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.