close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Amir_2011KEGG: sfu:Sfum_3154 hypothetical protein. (293 aa)    
Predicted Functional Partners:
Amir_2012
PFAM: peptidase S8 and S53 subtilisin kexin sedolisin; proteinase inhibitor I9 subtilisin propeptide; KEGG: mca:MCA0875 serine protease.
       0.507
Amir_2010
Two component transcriptional regulator, LuxR family; PFAM: response regulator receiver; regulatory protein LuxR; Sigma-70 region 4 type 2; SMART: response regulator receiver; regulatory protein LuxR; KEGG: scl:sce5431 two-component system response regulator.
       0.476
Amir_2009
PFAM: histidine kinase dimerization and phosphoacceptor region; ATP-binding region ATPase domain protein; KEGG: scl:sce5432 putative two-component system sensor kinase.
       0.462
Amir_1675
PFAM: protein of unknown function DUF405; protein of unknown function DUF418; KEGG: bha:BH0583 hypothetical protein.
 
     0.450
Amir_0038
PFAM: aminoglycoside phosphotransferase; KEGG: bcz:BCZK4351 homoserine kinase type II (protein kinase fold).
  
     0.446
Amir_0040
PFAM: copper resistance D domain protein; KEGG: bja:bll4878 copper export protein.
  
     0.434
Amir_1102
Transcriptional regulator, XRE family; PFAM: helix-turn-helix domain protein; SMART: helix-turn-helix domain protein; KEGG: gur:Gura_1136 helix-turn-helix domain- containing protein.
  
     0.418
Amir_0931
PFAM: Methyltransferase type 12; Methyltransferase type 11; KEGG: smt:Smal_2740 ubiquinone biosynthesis O- methyltransferase.
  
     0.415
Your Current Organism:
Actinosynnema mirum
NCBI taxonomy Id: 446462
Other names: A. mirum DSM 43827, Actinosynnema mirum DSM 43827, Actinosynnema mirum str. DSM 43827, Actinosynnema mirum strain DSM 43827
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.