STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ackA-2Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (363 aa)    
Predicted Functional Partners:
Amir_2275
PFAM: AMP-dependent synthetase and ligase; KEGG: eba:ebA1206 putative acetyl-coenzyme A synthetase.
   
 
 0.951
acsA
acetate/CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.
   
 
 0.950
Amir_3376
PFAM: thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein domain protein TPP- binding; KEGG: scl:sce2120 pyruvate decarboxylase; Belongs to the TPP enzyme family.
    
 0.944
Amir_3368
Phosphoketolase; PFAM: D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase; KEGG: mno:Mnod_8717 D-xylulose 5-phosphate/D- fructose 6-phosphate phosphoketolase.
  
 0.937
Amir_1089
PFAM: Aldehyde Dehydrogenase; KEGG: mxa:MXAN_5040 aldehyde dehydrogenase family protein; Belongs to the aldehyde dehydrogenase family.
 
 
 0.913
Amir_5955
PFAM: acylphosphatase; KEGG: met:M446_0372 acylphosphatase.
     
 0.910
Amir_1074
Lactate 2-monooxygenase; PFAM: FMN-dependent alpha-hydroxy acid dehydrogenase; KEGG: hypothetical protein; K00101 L-lactate dehydrogenase (cytochrome).
     
 0.907
ackA
Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family.
  
  
 
0.907
Amir_2006
TIGRFAM: isocitrate lyase; PFAM: isocitrate lyase and phosphorylmutase; KEGG: sml:Smlt0232 putative isocitrate lyase.
   
  
 0.875
Amir_1918
Phosphoketolase; PFAM: D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase; KEGG: bja:bll2518 putative phosphoketolase.
  
 0.741
Your Current Organism:
Actinosynnema mirum
NCBI taxonomy Id: 446462
Other names: A. mirum DSM 43827, Actinosynnema mirum DSM 43827, Actinosynnema mirum str. DSM 43827, Actinosynnema mirum strain DSM 43827
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