STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
polADNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (888 aa)    
Predicted Functional Partners:
Amir_0002
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
 
 0.992
recA
recA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
 
 0.990
Amir_0251
KEGG: sus:Acid_0002 DNA polymerase III, beta subunit; TIGRFAM: DNA polymerase III, beta subunit; PFAM: DNA polymerase III beta chain; SMART: DNA polymerase III beta chain.
 
 0.989
Amir_0475
PFAM: metallophosphoesterase; KEGG: serine/threonine protein phosphatase.
  
 0.967
sbcD
Nuclease SbcCD, D subunit; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family.
  
 0.967
Amir_2438
PFAM: metallophosphoesterase; KEGG: scl:sce7166 DNA repair exonuclease family protein.
  
 0.967
Amir_0595
KEGG: rpe:RPE_2170 hypothetical protein.
   
 0.962
Amir_0294
KEGG: dal:Dalk_0024 DNA-directed DNA polymerase.
  
 0.943
Amir_1078
PFAM: DNA-directed DNA polymerase; SMART: DNA-directed DNA polymerase; KEGG: hha:Hhal_2421 DNA polymerase I.
  
 
0.942
Amir_1378
KEGG: tbd:Tbd_0827 DNA polymerase III, epsilon subunit; TIGRFAM: DNA polymerase III, epsilon subunit; PFAM: Exonuclease RNase T and DNA polymerase III; Excinuclease ABC C subunit domain protein; SMART: Exonuclease; Excinuclease ABC C subunit domain protein.
 
 
 
 0.927
Your Current Organism:
Actinosynnema mirum
NCBI taxonomy Id: 446462
Other names: A. mirum DSM 43827, Actinosynnema mirum DSM 43827, Actinosynnema mirum str. DSM 43827, Actinosynnema mirum strain DSM 43827
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