node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Amir_2783 | Amir_2846 | Amir_2783 | Amir_2846 | PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: aav:Aave_3768 threonine dehydratase. | PFAM: thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein domain protein TPP- binding; KEGG: rme:Rmet_5039 acetolactate synthase, large subunit; Belongs to the TPP enzyme family. | 0.938 |
Amir_2783 | Amir_4633 | Amir_2783 | Amir_4633 | PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: aav:Aave_3768 threonine dehydratase. | PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: met:M446_6836 threonine dehydratase. | 0.924 |
Amir_2783 | Amir_4859 | Amir_2783 | Amir_4859 | PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: aav:Aave_3768 threonine dehydratase. | PFAM: thiamine pyrophosphate protein central region; thiamine pyrophosphate protein domain protein TPP- binding; thiamine pyrophosphate protein TPP binding domain protein; KEGG: eba:ebA4751 acetolactate synthase catalytic subunit; Belongs to the TPP enzyme family. | 0.937 |
Amir_2783 | Amir_6020 | Amir_2783 | Amir_6020 | PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: aav:Aave_3768 threonine dehydratase. | TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: gur:Gura_3719 acetolactate synthase 3 regulatory subunit. | 0.963 |
Amir_2783 | Amir_6021 | Amir_2783 | Amir_6021 | PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: aav:Aave_3768 threonine dehydratase. | TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; KEGG: ade:Adeh_1978 acetolactate synthase, large subunit. | 0.938 |
Amir_2783 | ilvC | Amir_2783 | Amir_6019 | PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: aav:Aave_3768 threonine dehydratase. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.687 |
Amir_2783 | leuB | Amir_2783 | Amir_6014 | PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: aav:Aave_3768 threonine dehydratase. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. | 0.945 |
Amir_2783 | leuD | Amir_2783 | Amir_6005 | PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: aav:Aave_3768 threonine dehydratase. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.451 |
Amir_2846 | Amir_2783 | Amir_2846 | Amir_2783 | PFAM: thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein domain protein TPP- binding; KEGG: rme:Rmet_5039 acetolactate synthase, large subunit; Belongs to the TPP enzyme family. | PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: aav:Aave_3768 threonine dehydratase. | 0.938 |
Amir_2846 | Amir_4633 | Amir_2846 | Amir_4633 | PFAM: thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein domain protein TPP- binding; KEGG: rme:Rmet_5039 acetolactate synthase, large subunit; Belongs to the TPP enzyme family. | PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: met:M446_6836 threonine dehydratase. | 0.941 |
Amir_2846 | Amir_4859 | Amir_2846 | Amir_4859 | PFAM: thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein domain protein TPP- binding; KEGG: rme:Rmet_5039 acetolactate synthase, large subunit; Belongs to the TPP enzyme family. | PFAM: thiamine pyrophosphate protein central region; thiamine pyrophosphate protein domain protein TPP- binding; thiamine pyrophosphate protein TPP binding domain protein; KEGG: eba:ebA4751 acetolactate synthase catalytic subunit; Belongs to the TPP enzyme family. | 0.927 |
Amir_2846 | Amir_6020 | Amir_2846 | Amir_6020 | PFAM: thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein domain protein TPP- binding; KEGG: rme:Rmet_5039 acetolactate synthase, large subunit; Belongs to the TPP enzyme family. | TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: gur:Gura_3719 acetolactate synthase 3 regulatory subunit. | 0.998 |
Amir_2846 | Amir_6021 | Amir_2846 | Amir_6021 | PFAM: thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein domain protein TPP- binding; KEGG: rme:Rmet_5039 acetolactate synthase, large subunit; Belongs to the TPP enzyme family. | TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; KEGG: ade:Adeh_1978 acetolactate synthase, large subunit. | 0.924 |
Amir_2846 | ilvC | Amir_2846 | Amir_6019 | PFAM: thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein domain protein TPP- binding; KEGG: rme:Rmet_5039 acetolactate synthase, large subunit; Belongs to the TPP enzyme family. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.995 |
Amir_2846 | leuA | Amir_2846 | Amir_0213 | PFAM: thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein domain protein TPP- binding; KEGG: rme:Rmet_5039 acetolactate synthase, large subunit; Belongs to the TPP enzyme family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.917 |
Amir_2846 | leuB | Amir_2846 | Amir_6014 | PFAM: thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein domain protein TPP- binding; KEGG: rme:Rmet_5039 acetolactate synthase, large subunit; Belongs to the TPP enzyme family. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. | 0.977 |
Amir_2846 | leuC | Amir_2846 | Amir_6006 | PFAM: thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein domain protein TPP- binding; KEGG: rme:Rmet_5039 acetolactate synthase, large subunit; Belongs to the TPP enzyme family. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.695 |
Amir_2846 | leuD | Amir_2846 | Amir_6005 | PFAM: thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein domain protein TPP- binding; KEGG: rme:Rmet_5039 acetolactate synthase, large subunit; Belongs to the TPP enzyme family. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.736 |
Amir_4633 | Amir_2783 | Amir_4633 | Amir_2783 | PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: met:M446_6836 threonine dehydratase. | PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: aav:Aave_3768 threonine dehydratase. | 0.924 |
Amir_4633 | Amir_2846 | Amir_4633 | Amir_2846 | PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: met:M446_6836 threonine dehydratase. | PFAM: thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein domain protein TPP- binding; KEGG: rme:Rmet_5039 acetolactate synthase, large subunit; Belongs to the TPP enzyme family. | 0.941 |