node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Amir_0217 | Amir_0702 | Amir_0217 | Amir_0702 | KEGG: tgr:Tgr7_1290 aspartate kinase; TIGRFAM: aspartate kinase; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; Belongs to the aspartokinase family. | Cystathionine gamma-synthase; PFAM: Cys/Met metabolism pyridoxal-phosphate- dependent protein; aromatic amino acid beta-eliminating lyase/threonine aldolase; KEGG: afw:Anae109_3845 cystathionine gamma-lyase. | 0.403 |
Amir_0217 | Amir_2211 | Amir_0217 | Amir_2211 | KEGG: tgr:Tgr7_1290 aspartate kinase; TIGRFAM: aspartate kinase; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; Belongs to the aspartokinase family. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.782 |
Amir_0217 | Amir_6156 | Amir_0217 | Amir_6156 | KEGG: tgr:Tgr7_1290 aspartate kinase; TIGRFAM: aspartate kinase; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; Belongs to the aspartokinase family. | PFAM: homoserine dehydrogenase; amino acid-binding ACT domain protein; homoserine dehydrogenase NAD-binding; KEGG: gme:Gmet_1629 homoserine dehydrogenase. | 0.989 |
Amir_0217 | metXA | Amir_0217 | Amir_6239 | KEGG: tgr:Tgr7_1290 aspartate kinase; TIGRFAM: aspartate kinase; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; Belongs to the aspartokinase family. | Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. | 0.859 |
Amir_0435 | Amir_0700 | Amir_0435 | Amir_0700 | KEGG: mag:amb0603 phosphatidylserine synthase; TIGRFAM: CDP-diacylglycerol/serine O- phosphatidyltransferase; PFAM: CDP-alcohol phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | Cystathionine beta-synthase; KEGG: afw:Anae109_3846 pyridoxal-5'-phosphate- dependent protein beta subunit; TIGRFAM: cystathionine beta-synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; CBS domain containing protein; SMART: CBS domain containing protein. | 0.900 |
Amir_0435 | Amir_2211 | Amir_0435 | Amir_2211 | KEGG: mag:amb0603 phosphatidylserine synthase; TIGRFAM: CDP-diacylglycerol/serine O- phosphatidyltransferase; PFAM: CDP-alcohol phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.422 |
Amir_0435 | Amir_2783 | Amir_0435 | Amir_2783 | KEGG: mag:amb0603 phosphatidylserine synthase; TIGRFAM: CDP-diacylglycerol/serine O- phosphatidyltransferase; PFAM: CDP-alcohol phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: aav:Aave_3768 threonine dehydratase. | 0.901 |
Amir_0435 | glyA | Amir_0435 | Amir_5659 | KEGG: mag:amb0603 phosphatidylserine synthase; TIGRFAM: CDP-diacylglycerol/serine O- phosphatidyltransferase; PFAM: CDP-alcohol phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.900 |
Amir_0435 | metXA | Amir_0435 | Amir_6239 | KEGG: mag:amb0603 phosphatidylserine synthase; TIGRFAM: CDP-diacylglycerol/serine O- phosphatidyltransferase; PFAM: CDP-alcohol phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. | 0.829 |
Amir_0700 | Amir_0435 | Amir_0700 | Amir_0435 | Cystathionine beta-synthase; KEGG: afw:Anae109_3846 pyridoxal-5'-phosphate- dependent protein beta subunit; TIGRFAM: cystathionine beta-synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; CBS domain containing protein; SMART: CBS domain containing protein. | KEGG: mag:amb0603 phosphatidylserine synthase; TIGRFAM: CDP-diacylglycerol/serine O- phosphatidyltransferase; PFAM: CDP-alcohol phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.900 |
Amir_0700 | Amir_0702 | Amir_0700 | Amir_0702 | Cystathionine beta-synthase; KEGG: afw:Anae109_3846 pyridoxal-5'-phosphate- dependent protein beta subunit; TIGRFAM: cystathionine beta-synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; CBS domain containing protein; SMART: CBS domain containing protein. | Cystathionine gamma-synthase; PFAM: Cys/Met metabolism pyridoxal-phosphate- dependent protein; aromatic amino acid beta-eliminating lyase/threonine aldolase; KEGG: afw:Anae109_3845 cystathionine gamma-lyase. | 0.996 |
Amir_0700 | Amir_2211 | Amir_0700 | Amir_2211 | Cystathionine beta-synthase; KEGG: afw:Anae109_3846 pyridoxal-5'-phosphate- dependent protein beta subunit; TIGRFAM: cystathionine beta-synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; CBS domain containing protein; SMART: CBS domain containing protein. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.949 |
Amir_0700 | Amir_2783 | Amir_0700 | Amir_2783 | Cystathionine beta-synthase; KEGG: afw:Anae109_3846 pyridoxal-5'-phosphate- dependent protein beta subunit; TIGRFAM: cystathionine beta-synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; CBS domain containing protein; SMART: CBS domain containing protein. | PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: aav:Aave_3768 threonine dehydratase. | 0.916 |
Amir_0700 | Amir_4016 | Amir_0700 | Amir_4016 | Cystathionine beta-synthase; KEGG: afw:Anae109_3846 pyridoxal-5'-phosphate- dependent protein beta subunit; TIGRFAM: cystathionine beta-synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; CBS domain containing protein; SMART: CBS domain containing protein. | KEGG: sus:Acid_5487 O-acetylhomoserine/O- acetylserine sulfhydrylase; TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism pyridoxal-phosphate- dependent protein; DegT/DnrJ/EryC1/StrS aminotransferase; aromatic amino acid beta-eliminating lyase/threonine aldolase. | 0.940 |
Amir_0700 | Amir_6156 | Amir_0700 | Amir_6156 | Cystathionine beta-synthase; KEGG: afw:Anae109_3846 pyridoxal-5'-phosphate- dependent protein beta subunit; TIGRFAM: cystathionine beta-synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; CBS domain containing protein; SMART: CBS domain containing protein. | PFAM: homoserine dehydrogenase; amino acid-binding ACT domain protein; homoserine dehydrogenase NAD-binding; KEGG: gme:Gmet_1629 homoserine dehydrogenase. | 0.907 |
Amir_0700 | Amir_6240 | Amir_0700 | Amir_6240 | Cystathionine beta-synthase; KEGG: afw:Anae109_3846 pyridoxal-5'-phosphate- dependent protein beta subunit; TIGRFAM: cystathionine beta-synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; CBS domain containing protein; SMART: CBS domain containing protein. | O-acetylhomoserine/O-acetylserine sulfhydrylase; KEGG: bha:BH2603 O-acetylhomoserine aminocarboxypropyltransferase; TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism pyridoxal-phosphate- dependent protein; aromatic amino acid beta-eliminating lyase/threonine aldolase. | 0.941 |
Amir_0700 | glyA | Amir_0700 | Amir_5659 | Cystathionine beta-synthase; KEGG: afw:Anae109_3846 pyridoxal-5'-phosphate- dependent protein beta subunit; TIGRFAM: cystathionine beta-synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; CBS domain containing protein; SMART: CBS domain containing protein. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.947 |
Amir_0700 | metXA | Amir_0700 | Amir_6239 | Cystathionine beta-synthase; KEGG: afw:Anae109_3846 pyridoxal-5'-phosphate- dependent protein beta subunit; TIGRFAM: cystathionine beta-synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; CBS domain containing protein; SMART: CBS domain containing protein. | Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. | 0.844 |
Amir_0702 | Amir_0217 | Amir_0702 | Amir_0217 | Cystathionine gamma-synthase; PFAM: Cys/Met metabolism pyridoxal-phosphate- dependent protein; aromatic amino acid beta-eliminating lyase/threonine aldolase; KEGG: afw:Anae109_3845 cystathionine gamma-lyase. | KEGG: tgr:Tgr7_1290 aspartate kinase; TIGRFAM: aspartate kinase; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; Belongs to the aspartokinase family. | 0.403 |
Amir_0702 | Amir_0700 | Amir_0702 | Amir_0700 | Cystathionine gamma-synthase; PFAM: Cys/Met metabolism pyridoxal-phosphate- dependent protein; aromatic amino acid beta-eliminating lyase/threonine aldolase; KEGG: afw:Anae109_3845 cystathionine gamma-lyase. | Cystathionine beta-synthase; KEGG: afw:Anae109_3846 pyridoxal-5'-phosphate- dependent protein beta subunit; TIGRFAM: cystathionine beta-synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; CBS domain containing protein; SMART: CBS domain containing protein. | 0.996 |