STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Cfla_2071DNA polymerase III, epsilon subunit; SMART: Exonuclease; Excinuclease ABC C subunit domain protein; TIGRFAM: DNA polymerase III, epsilon subunit; KEGG: DNA polymerase III, epsilon subunit; PFAM: Exonuclease RNase T and DNA polymerase III; Excinuclease ABC C subunit domain protein. (631 aa)    
Predicted Functional Partners:
uvrB
Excinuclease ABC, B subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...]
 
 
 0.953
Cfla_2228
KEGG: bcv:Bcav_1739 DNA polymerase III, delta subunit; TIGRFAM: DNA polymerase III, delta subunit; PFAM: DNA polymerase III delta.
    
 0.952
Cfla_0576
TIGRFAM: DNA polymerase III, delta prime subunit; KEGG: DNA polymerase III, delta prime subunit; SMART: AAA ATPase.
 
 0.951
Cfla_1606
TIGRFAM: DNA polymerase III, alpha subunit; PFAM: DNA polymerase III alpha subunit; nucleic acid binding OB-fold tRNA/helicase-type; PHP domain protein; KEGG: DNA polymerase III, alpha subunit; SMART: phosphoesterase PHP domain protein.
    
 0.944
Cfla_3125
SMART: AAA ATPase; TIGRFAM: DNA polymerase III, subunits gamma and tau; KEGG: DNA polymerase III, subunits gamma and tau; PFAM: AAA ATPase central domain protein.
  
 0.942
Cfla_0002
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
   
 0.940
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
 
 
 
 0.908
Cfla_2854
PFAM: UvrD/REP helicase; KEGG: fra:Francci3_3792 UvrD/REP helicase.
 
  
 0.839
Cfla_2072
PFAM: Transcription regulator, AsnC-type-like; KEGG: bcv:Bcav_1895 transcriptional regulator, AsnC family.
       0.830
Cfla_2474
PFAM: UvrD/REP helicase; KEGG: UvrD/REP helicase.
 
  
 0.824
Your Current Organism:
Cellulomonas flavigena
NCBI taxonomy Id: 446466
Other names: C. flavigena DSM 20109, Cellulomonas flavigena DSM 20109, Cellulomonas flavigena str. DSM 20109, Cellulomonas flavigena strain DSM 20109
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