node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cfla_0074 | Cfla_1721 | Cfla_0074 | Cfla_1721 | TIGRFAM: malate synthase A; KEGG: aau:AAur_0721 malate synthase; PFAM: Malate synthase family protein; Belongs to the malate synthase family. | TIGRFAM: formate acetyltransferase; KEGG: jde:Jden_1398 formate acetyltransferase; PFAM: pyruvate formate-lyase PFL; formate C- acetyltransferase glycine radical. | 0.900 |
Cfla_0074 | fumC | Cfla_0074 | Cfla_0959 | TIGRFAM: malate synthase A; KEGG: aau:AAur_0721 malate synthase; PFAM: Malate synthase family protein; Belongs to the malate synthase family. | Fumarate lyase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. | 0.921 |
Cfla_0074 | mdh | Cfla_0074 | Cfla_2522 | TIGRFAM: malate synthase A; KEGG: aau:AAur_0721 malate synthase; PFAM: Malate synthase family protein; Belongs to the malate synthase family. | Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. | 0.923 |
Cfla_0074 | mqo | Cfla_0074 | Cfla_1908 | TIGRFAM: malate synthase A; KEGG: aau:AAur_0721 malate synthase; PFAM: Malate synthase family protein; Belongs to the malate synthase family. | TIGRFAM: malate/quinone oxidoreductase; KEGG: bcv:Bcav_0816 malate/quinone oxidoreductase; PFAM: Malate:quinone-oxidoreductase. | 0.919 |
Cfla_0074 | purU | Cfla_0074 | Cfla_2508 | TIGRFAM: malate synthase A; KEGG: aau:AAur_0721 malate synthase; PFAM: Malate synthase family protein; Belongs to the malate synthase family. | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). | 0.800 |
Cfla_1528 | gcvT | Cfla_1528 | Cfla_0094 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.911 |
Cfla_1528 | glyA | Cfla_1528 | Cfla_2501 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.918 |
Cfla_1528 | purN | Cfla_1528 | Cfla_2533 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.911 |
Cfla_1528 | purU | Cfla_1528 | Cfla_2508 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). | 0.907 |
Cfla_1721 | Cfla_0074 | Cfla_1721 | Cfla_0074 | TIGRFAM: formate acetyltransferase; KEGG: jde:Jden_1398 formate acetyltransferase; PFAM: pyruvate formate-lyase PFL; formate C- acetyltransferase glycine radical. | TIGRFAM: malate synthase A; KEGG: aau:AAur_0721 malate synthase; PFAM: Malate synthase family protein; Belongs to the malate synthase family. | 0.900 |
Cfla_1721 | mdh | Cfla_1721 | Cfla_2522 | TIGRFAM: formate acetyltransferase; KEGG: jde:Jden_1398 formate acetyltransferase; PFAM: pyruvate formate-lyase PFL; formate C- acetyltransferase glycine radical. | Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. | 0.829 |
Cfla_1721 | purU | Cfla_1721 | Cfla_2508 | TIGRFAM: formate acetyltransferase; KEGG: jde:Jden_1398 formate acetyltransferase; PFAM: pyruvate formate-lyase PFL; formate C- acetyltransferase glycine radical. | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). | 0.811 |
folD | gcvT | Cfla_2500 | Cfla_0094 | Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.953 |
folD | glyA | Cfla_2500 | Cfla_2501 | Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.998 |
folD | purN | Cfla_2500 | Cfla_2533 | Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.973 |
folD | purU | Cfla_2500 | Cfla_2508 | Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). | 0.977 |
fumC | Cfla_0074 | Cfla_0959 | Cfla_0074 | Fumarate lyase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. | TIGRFAM: malate synthase A; KEGG: aau:AAur_0721 malate synthase; PFAM: Malate synthase family protein; Belongs to the malate synthase family. | 0.921 |
fumC | mdh | Cfla_0959 | Cfla_2522 | Fumarate lyase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. | Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. | 0.980 |
fumC | mqo | Cfla_0959 | Cfla_1908 | Fumarate lyase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. | TIGRFAM: malate/quinone oxidoreductase; KEGG: bcv:Bcav_0816 malate/quinone oxidoreductase; PFAM: Malate:quinone-oxidoreductase. | 0.971 |
fumC | purU | Cfla_0959 | Cfla_2508 | Fumarate lyase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). | 0.805 |