STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
Ndas_0572COGs: COG0749 DNA polymerase I - 3'-5' exonuclease and polymerase domains; InterPro IPR001098:IPR002298; KEGG: sro:Sros_6678 DNA polymerase I - 3'-5' exonuclease and polymerase domains-like protein; PFAM: DNA-directed DNA polymerase; SMART: DNA-directed DNA polymerase; SPTR: C1YLH9 DNA polymerase I family protein with 3'-5'-exonuclease and polymerase domains; PFAM: DNA polymerase family A. (554 aa)    
Predicted Functional Partners:
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 
0.958
sbcD
Nuclease SbcCD, D subunit; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family.
  
 0.669
msrA
Peptide methionine sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
   
  
 0.606
Ndas_3166
COGs: COG0069 Glutamate synthase domain 2; InterProIPR000583:IPR006982:IPR002932:IPR002489:IPR 013785:IPR001202:IPR017932; KEGG: tfu:Tfu_1173 glutamate synthase (NADH) large subunit; PFAM: ferredoxin-dependent glutamate synthase; glutamine amidotransferase class-II; glutamate synthase; glutamate synthase alpha subunit domain protein; PRIAM: Glutamate synthase (ferredoxin); SPTR: C1YUQ7 Glutamate synthase (NADH) large subunit; PFAM: Conserved region in glutamate synthase; GXGXG motif; Glutamate synthase central domain; Glutamine amidotransferases class-II.
      
 0.604
mutM
formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
  
  
 0.602
Ndas_3660
DNA-(apurinic or apyrimidinic site) lyase; COGs: COG0266 Formamidopyrimidine-DNA glycosylase; InterProIPR010979:IPR012319:IPR015886:IPR015887:IPR 000214; KEGG: tfu:Tfu_0694 putative DNA repair hydrolase; PFAM: DNA glycosylase/AP lyase, H2TH DNA-binding; Formamidopyrimidine-DNA glycosylase catalytic domain protein; PRIAM: DNA-(apurinic or apyrimidinic site) lyase; SPTR: C1YR34 DNA glycosylase; PFAM: Formamidopyrimidine-DNA glycosylase H2TH domain; Formamidopyrimidine-DNA glycosylase N-terminal domain; Zinc finger found in FPG and IleRS; Belongs to the FPG family.
  
  
 0.602
glyQS
glycyl-tRNA synthetase; Catalyzes the attachment of glycine to tRNA(Gly). Belongs to the class-II aminoacyl-tRNA synthetase family.
   
 
 0.561
pheT
COGs: COG0072 Phenylalanyl-tRNA synthetase beta subunit; InterProIPR005121:IPR005146:IPR002547:IPR005147:IPR 004532:IPR020825:IPR012340:IPR016027:IPR009061; KEGG: tfu:Tfu_2060 phenylalanyl-tRNA synthetase subunit beta; PFAM: B3/4 domain protein; tRNA synthetase B5; t-RNA-binding domain protein; ferredoxin-fold anticodon-binding; PRIAM: Phenylalanine--tRNA ligase; SMART: B3/4 domain protein; ferredoxin-fold anticodon-binding; tRNA synthetase B5; SPTR: C1YVE0 Phenylalanyl-tRNA synthetase beta subunit; TIGRFAM: phenylalanyl-tRNA synthetase, beta subunit; PFAM: tRNA synthetase B5 domain; B [...]
  
  
 0.560
guaA
GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP.
  
  
 0.540
Ndas_0732
Lipolytic protein G-D-S-L family; COGs: COG2755 Lysophospholipase L1 and related esterase; InterPro IPR001087:IPR013831:IPR013830; KEGG: tfu:Tfu_0855 hypothetical protein; PFAM: lipolytic protein G-D-S-L family; SPTR: C1YNC7 Lysophospholipase L1-like esterase; PFAM: GDSL-like Lipase/Acylhydrolase.
  
     0.530
Your Current Organism:
Nocardiopsis dassonvillei
NCBI taxonomy Id: 446468
Other names: N. dassonvillei subsp. dassonvillei DSM 43111, Nocardiopsis dassonvillei DSM 43111, Nocardiopsis dassonvillei subsp. dassonvillei DSM 43111, Nocardiopsis dassonvillei subsp. dassonvillei str. DSM 43111, Nocardiopsis dassonvillei subsp. dassonvillei strain DSM 43111
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