STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
ribH6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (157 aa)    
Predicted Functional Partners:
Ndas_0860
COGs: COG0307 Riboflavin synthase alpha chain; InterPro IPR001783:IPR017938; KEGG: kra:Krad_2979 riboflavin synthase, alpha subunit; PFAM: Lumazine-binding protein; PRIAM: Riboflavin synthase; SPTR: C1YQN7 Riboflavin synthase, alpha subunit; TIGRFAM: riboflavin synthase, alpha subunit; PFAM: Lumazine binding domain; TIGRFAM: riboflavin synthase, alpha subunit.
 
 0.999
ribBA
3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family.
 
 
 0.999
metK
S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
 
 
 0.949
Ndas_3585
Riboflavin biosynthesis protein RibF; COGs: COG0196 FAD synthase; InterProIPR015865:IPR004821:IPR002606:IPR015864:IPR 014729; KEGG: tcu:Tcur_3326 riboflavin biosynthesis protein RibF; PFAM: FAD synthetase; Riboflavin kinase; SPTR: C1YQZ2 Riboflavin kinase; FMN adenylyltransferase; TIGRFAM: riboflavin biosynthesis protein RibF; cytidyltransferase-related domain protein; PFAM: Riboflavin kinase; FAD synthetase; TIGRFAM: riboflavin kinase/FMN adenylyltransferase; cytidyltransferase-related domain; Belongs to the ribF family.
  
  
 0.927
Ndas_4091
COGs: COG1970 Large-conductance mechanosensitive channel; InterPro IPR001185; KEGG: tcu:Tcur_0902 large conductance mechanosensitive channel protein; PFAM: large-conductance mechanosensitive channel; SPTR: C1YSG5 Large conductance mechanosensitive channel protein; TIGRFAM: large conductance mechanosensitive channel protein; PFAM: Large-conductance mechanosensitive channel, MscL; TIGRFAM: large conductance mechanosensitive channel protein.
  
  
 0.923
Ndas_0771
CMP/dCMP deaminase zinc-binding protein; COGs: COG0117 Pyrimidine deaminase; InterPro IPR002125:IPR016193; KEGG: tfu:Tfu_0877 5-amino-6-(5-phosphoribosylamino)uracil reductase; PFAM: CMP/dCMP deaminase zinc-binding; SPTR: C1YN82 Pyrimidine deaminase; PFAM: Cytidine and deoxycytidylate deaminase zinc-binding region.
 
 
 0.895
pyrB
COGs: COG0540 Aspartate carbamoyltransferase catalytic chain; InterPro IPR006132:IPR006130:IPR006131:IPR002082; KEGG: tfu:Tfu_1054 aspartate carbamoyltransferase catalytic subunit; PFAM: aspartate/ornithine carbamoyltransferase carbamoyl-P binding domain; aspartate/ornithine carbamoyltransferase Asp/Orn-binding region; PRIAM: Aspartate carbamoyltransferase; SPTR: C1YWG9 Aspartate carbamoyltransferase; TIGRFAM: aspartate carbamoyltransferase; PFAM: Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; TIGR [...]
  
    0.876
Ndas_0770
Bifunctional deaminase-reductase domain protein; COGs: COG1985 Pyrimidine reductase riboflavin biosynthesis; InterPro IPR002734; KEGG: tcu:Tcur_1829 bifunctional deaminase-reductase domain protein; PFAM: bifunctional deaminase-reductase domain protein; SPTR: C1YN83 Pyrimidine reductase, riboflavin biosynthesis; PFAM: RibD C-terminal domain; TIGRFAM: riboflavin-specific deaminase C-terminal domain.
 
 
 0.859
Ndas_0855
Fmu (Sun) domain protein; COGs: COG0144 tRNA and rRNA cytosine-C5-methylase; InterPro IPR018314:IPR006027:IPR001678; KEGG: tfu:Tfu_1076 putative RNA-binding Sun protein; PFAM: Fmu (Sun) domain protein; NusB/RsmB/TIM44; SPTR: C1YQP2 tRNA/rRNA cytosine-C5-methylase; PFAM: NOL1/NOP2/sun family; NusB family; TIGRFAM: ribosomal RNA small subunit methyltransferase RsmB; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
  
  
 0.842
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
  
 
 0.829
Your Current Organism:
Nocardiopsis dassonvillei
NCBI taxonomy Id: 446468
Other names: N. dassonvillei subsp. dassonvillei DSM 43111, Nocardiopsis dassonvillei DSM 43111, Nocardiopsis dassonvillei subsp. dassonvillei DSM 43111, Nocardiopsis dassonvillei subsp. dassonvillei str. DSM 43111, Nocardiopsis dassonvillei subsp. dassonvillei strain DSM 43111
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