STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Cooccurrence
Coexpression
Experiments
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[Homology]
Score
hemLGlutamate-1-semialdehyde-2,1-aminomutase; COGs: COG0001 Glutamate-1-semialdehyde aminotransferase; InterPro IPR005814:IPR015424:IPR015421:IPR004639; KEGG: tfu:Tfu_2726 glutamate-1-semialdehyde aminotransferase; PFAM: aminotransferase class-III; SPTR: C1YGQ1 Glutamate-1-semialdehyde 2,1-aminomutase; TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; PFAM: Aminotransferase class-III; TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase. (431 aa)    
Predicted Functional Partners:
Ndas_4369
Porphobilinogen synthase; COGs: COG0113 Delta-aminolevulinic acid dehydratase; InterPro IPR001731:IPR013785; KEGG: tfu:Tfu_2730 delta-aminolevulinic acid dehydratase; PFAM: delta-aminolevulinic acid dehydratase; PRIAM: Porphobilinogen synthase; SPTR: C1YGP1 Delta-aminolevulinic acid dehydratase; PFAM: Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.
 
 
 0.997
hemA
glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
 
 0.995
hemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
 
  
 0.959
Ndas_1745
Amino acid adenylation domain protein; COGs: COG1020 Non-ribosomal peptide synthetase modules and related protein; InterProIPR020459:IPR009081:IPR020845:IPR010071:IPR 000873:IPR006163; KEGG: tfu:Tfu_1865 amino acid adenylation; PFAM: AMP-dependent synthetase and ligase; phosphopantetheine-binding; SPTR: C1YNY8 Amino acid adenylation enzyme/thioester reductase family protein; TIGRFAM: amino acid adenylation domain protein; PFAM: Phosphopantetheine attachment site; AMP-binding enzyme; TIGRFAM: amino acid adenylation domain; Belongs to the ATP-dependent AMP-binding enzyme family.
  
 
 0.923
Ndas_4358
Phosphoglycerate mutase; COGs: COG0406 Fructose-2 6-bisphosphatase; InterPro IPR013078; KEGG: tfu:Tfu_2725 putative phosphoglycerate mutase; PFAM: Phosphoglycerate mutase; SMART: Phosphoglycerate mutase; SPTR: C1YGQ2 Fructose-2,6-bisphosphatase; PFAM: Phosphoglycerate mutase family.
  
    0.910
Ndas_0495
COGs: COG3321 Polyketide synthase modules and related protein; InterProIPR009081:IPR018201:IPR014030:IPR006162:IPR 016036:IPR001227:IPR016035:IPR006163:IPR020841:IPR014031:I PR016039:IPR016038:IPR014043; KEGG: mpa:MAP1371 Pks8; PFAM: Beta-ketoacyl synthase; phosphopantetheine-binding; Acyl transferase; PRIAM: 6-deoxyerythronolide-B synthase; SMART: Polyketide synthase, beta-ketoacyl synthase region; SPTR: C1YLQ5 Polyketide synthase family protein; PFAM: Acyl transferase domain; Phosphopantetheine attachment site; Beta-ketoacyl synthase, N-terminal domain; Beta-ketoacyl synthase, C-term [...]
    
 0.906
Ndas_5008
Redoxin domain protein; COGs: COG0526 Thiol-disulfide isomerase and thioredoxins; InterProIPR017936:IPR017937:IPR012336:IPR012335:IPR 013740; KEGG: tfu:Tfu_2704 hypothetical protein; PFAM: Redoxin domain protein; SPTR: C1YIF6 Thiol-disulfide isomerase-like thioredoxin; PFAM: Redoxin.
  
  
 0.906
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
 
  
 0.895
Ndas_3431
uroporphyrin-III C-methyltransferase; COGs: COG0007 Uroporphyrinogen-III methylase; InterProIPR000878:IPR016040:IPR006367:IPR006366:IPR 014777:IPR014776; KEGG: tfu:Tfu_2221 uroporphyrinogen-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; SPTR: C1YQA3 Uroporphyrinogen-III C-methyltransferase; TIGRFAM: uroporphyrin-III C-methyltransferase; siroheme synthase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: uroporphyrin-III C-methyltransferase; siroheme synthase, N-terminal domain.
 
   
 0.876
Ndas_4370
Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; COGs: COG1587 Uroporphyrinogen-III synthase; InterProIPR000878:IPR003754:IPR003043:IPR014777:IPR 014776; KEGG: tfu:Tfu_2731 uroporphyrinogen-III C-methyltransferase / uroporphyrinogen-III synthase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Uroporphyrinogen III synthase HEM4; SPTR: C1YGP0 Uroporphyrinogen-III synthase; uroporphyrinogen-III C-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; Uroporphyrinogen-III synthase HemD.
 
  
 0.868
Your Current Organism:
Nocardiopsis dassonvillei
NCBI taxonomy Id: 446468
Other names: N. dassonvillei subsp. dassonvillei DSM 43111, Nocardiopsis dassonvillei DSM 43111, Nocardiopsis dassonvillei subsp. dassonvillei DSM 43111, Nocardiopsis dassonvillei subsp. dassonvillei str. DSM 43111, Nocardiopsis dassonvillei subsp. dassonvillei strain DSM 43111
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