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purA-2Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (427 aa)    
Predicted Functional Partners:
Ndas_2434
COGs: COG0015 Adenylosuccinate lyase; InterProIPR020557:IPR000362:IPR008948:IPR004769:IPR 019468; KEGG: sro:Sros_4439 adenylosuccinate lyase; K01756 adenylosuccinate lyase; PFAM: fumarate lyase; Adenylosuccinate lyase-like; SPTR: C1YM97 Adenylosuccinate lyase; TIGRFAM: adenylosuccinate lyase; PFAM: Lyase; Adenylosuccinate lyase C-terminus; TIGRFAM: adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
 
 0.987
purH
Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; COGs: COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful); InterPro IPR002695:IPR013982:IPR011607; KEGG: tfu:Tfu_2572 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: AICARFT/IMPCHase bienzyme formylation region; MGS domain protein; PRIAM: IMP cyclohydrolase; SMART: AICARFT/IMPCHase bienzyme formylation region; SPTR: C1YKN5 IMP cyclohydrolase; phosphoribosylaminoimidazolecarboxamide formyltransferase; TIGRFAM: phosphorib [...]
 
 0.981
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
 
 
 0.980
Ndas_0285
COGs: COG0516 IMP dehydrogenase/GMP reductase; InterProIPR013785:IPR001093:IPR000644:IPR005991:IPR 018529; KEGG: tfu:Tfu_2440 inosine 5-monophosphate dehydrogenase; PFAM: IMP dehydrogenase/GMP reductase; CBS domain containing protein; PRIAM: IMP dehydrogenase; SMART: CBS domain containing protein; SPTR: C1YHC2 IMP dehydrogenase family protein; TIGRFAM: IMP dehydrogenase family protein; PFAM: CBS domain; IMP dehydrogenase / GMP reductase domain; TIGRFAM: inosine-5'-monophosphate dehydrogenase; IMP dehydrogenase family protein.
 
 
 0.975
Ndas_4022
IMP dehydrogenase family protein; COGs: COG2070 Dioxygenase related to 2-nitropropane dioxygenase; InterPro IPR013785:IPR001093:IPR005992:IPR001412; KEGG: tfu:Tfu_2595 inosine 5-monophosphate dehydrogenase; PFAM: IMP dehydrogenase/GMP reductase; SPTR: C1YSM7 IMP dehydrogenase family protein; TIGRFAM: IMP dehydrogenase family protein; PFAM: IMP dehydrogenase / GMP reductase domain; TIGRFAM: IMP dehydrogenase family protein.
 
 
 0.972
guaA
GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP.
 
  
 0.957
Ndas_0386
Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
 
 0.945
Ndas_4969
COGs: COG0634 Hypoxanthine-guanine phosphoribosyltransferase; InterPro IPR005904:IPR000836; KEGG: tfu:Tfu_2896 hypoxanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; PRIAM: Hypoxanthine phosphoribosyltransferase; SPTR: C1YIJ4 Hypoxanthine phosphoribosyltransferase; TIGRFAM: hypoxanthine phosphoribosyltransferase; PFAM: Phosphoribosyl transferase domain; TIGRFAM: hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
  
 
 0.938
Ndas_4982
L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate.
     
 0.937
purE
Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).
  
 
 0.933
Your Current Organism:
Nocardiopsis dassonvillei
NCBI taxonomy Id: 446468
Other names: N. dassonvillei subsp. dassonvillei DSM 43111, Nocardiopsis dassonvillei DSM 43111, Nocardiopsis dassonvillei subsp. dassonvillei DSM 43111, Nocardiopsis dassonvillei subsp. dassonvillei str. DSM 43111, Nocardiopsis dassonvillei subsp. dassonvillei strain DSM 43111
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