STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (245 aa)    
Predicted Functional Partners:
Snas_3225
Exodeoxyribonuclease III Xth; KEGG: bcj:BCAL0487 endonuclease/exonuclease/phosphatase family protein; TIGRFAM: exodeoxyribonuclease III Xth; exodeoxyribonuclease III; PFAM: Endonuclease/exonuclease/phosphatase.
 
 0.980
Snas_1069
PFAM: NUDIX hydrolase; KEGG: pnu:Pnuc_0521 NUDIX hydrolase.
    
 0.939
Snas_1070
PFAM: alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; Thioredoxin domain; Redoxin domain protein; KEGG: mxa:MXAN_3252 thiol:disulfide interchange protein DsbE.
  
    0.844
Snas_2241
PFAM: Endonuclease/exonuclease/phosphatase; KEGG: hypothetical protein.
  
 0.809
Snas_1068
PFAM: Colicin V production protein; peptidase S1 and S6 chymotrypsin/Hap; KEGG: sat:SYN_01706 endopeptidase.
   
   0.730
mutM
formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
   
  
 0.700
Snas_6413
Apurinic endonuclease Apn1; KEGG: pca:Pcar_3071 endonuclease IV; TIGRFAM: apurinic endonuclease Apn1; PFAM: Xylose isomerase domain protein TIM barrel; SMART: AP endonuclease family 2.
  
 
 0.684
Snas_6080
PFAM: ExsB family protein; KEGG: mxa:MXAN_4063 hypothetical protein.
 
    0.674
Snas_1102
PFAM: HhH-GPD family protein; helix-hairpin-helix motif; SMART: HhH-GPD family protein; iron-sulfur cluster loop; KEGG: tgr:Tgr7_2945 A/G-specific DNA-adenine glycosylase.
 
  
0.660
Snas_6173
DNA-(apurinic or apyrimidinic site) lyase; PFAM: DNA glycosylase/AP lyase, H2TH DNA-binding; Formamidopyrimidine-DNA glycosylase catalytic domain protein; KEGG: hypothetical protein; Belongs to the FPG family.
   
  
 0.660
Your Current Organism:
Stackebrandtia nassauensis
NCBI taxonomy Id: 446470
Other names: S. nassauensis DSM 44728, Stackebrandtia nassauensis DSM 44728, Stackebrandtia nassauensis str. DSM 44728, Stackebrandtia nassauensis strain DSM 44728
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