Snas_4024 protein (Stackebrandtia nassauensis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

Snas_4024

Hypothetical protein. (125 aa)

Predicted Functional Partners:

Snas_4023

0.836

Snas_0149

0.727

Snas_5051

0.681

Snas_1090

0.666

Snas_1072

0.662

Snas_4540

0.655

Snas_3051

0.566

Snas_4537

0.561

Snas_6087

0.548

Snas_4935

0.539

Your Current Organism:

Stackebrandtia nassauensis

NCBI taxonomy Id: 446470
Other names: S. nassauensis DSM 44728, Stackebrandtia nassauensis DSM 44728, Stackebrandtia nassauensis str. DSM 44728, Stackebrandtia nassauensis strain DSM 44728

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
Snas_0149	Snas_1090	KEGG: hypothetical protein.	Hypothetical protein.	0.521
Snas_0149	Snas_3051	KEGG: hypothetical protein.	Hypothetical protein.	0.608
Snas_0149	Snas_4024	KEGG: hypothetical protein.	Hypothetical protein.	0.727
Snas_0149	Snas_4540	KEGG: hypothetical protein.	Hypothetical protein.	0.734
Snas_0149	Snas_4935	KEGG: hypothetical protein.	Hypothetical protein.	0.673
Snas_0149	Snas_5051	KEGG: hypothetical protein.	Hypothetical protein; Exonuclease that cleaves single-stranded 3' overhangs of double-stranded RNA.	0.712
Snas_0149	Snas_6087	KEGG: hypothetical protein.	TIGRFAM: chorismate mutase; PFAM: Chorismate mutase; KEGG: ppd:Ppro_1345 chorismate mutase.	0.675
Snas_1072	Snas_1090	KEGG: Hypothetical protein CBG02561.	Hypothetical protein.	0.424
Snas_1072	Snas_4024	KEGG: Hypothetical protein CBG02561.	Hypothetical protein.	0.662
Snas_1090	Snas_0149	Hypothetical protein.	KEGG: hypothetical protein.	0.521
Snas_1090	Snas_1072	Hypothetical protein.	KEGG: Hypothetical protein CBG02561.	0.424
Snas_1090	Snas_3051	Hypothetical protein.	Hypothetical protein.	0.472
Snas_1090	Snas_4024	Hypothetical protein.	Hypothetical protein.	0.666
Snas_1090	Snas_4540	Hypothetical protein.	Hypothetical protein.	0.731
Snas_1090	Snas_5051	Hypothetical protein.	Hypothetical protein; Exonuclease that cleaves single-stranded 3' overhangs of double-stranded RNA.	0.773
Snas_1090	Snas_6087	Hypothetical protein.	TIGRFAM: chorismate mutase; PFAM: Chorismate mutase; KEGG: ppd:Ppro_1345 chorismate mutase.	0.730
Snas_3051	Snas_0149	Hypothetical protein.	KEGG: hypothetical protein.	0.608
Snas_3051	Snas_1090	Hypothetical protein.	Hypothetical protein.	0.472
Snas_3051	Snas_4024	Hypothetical protein.	Hypothetical protein.	0.566
Snas_3051	Snas_4540	Hypothetical protein.	Hypothetical protein.	0.558

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

52

average node degree:

9.45

avg. local clustering coefficient:

0.939

expected number of edges:

10

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006869

Lipid transport

6 of 12

2.48

5.02

1.05e-10

GO:0051701

Biological process involved in interaction with host

5 of 66

1.66

2.04

1.11e-05

GO:0070508

Cholesterol import

2 of 2

2.78

1.46

0.0022

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005548

Phospholipid transporter activity

4 of 4

2.78

3.56

2.44e-07

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0043190

ATP-binding cassette (ABC) transporter complex

4 of 49

1.69

1.68

0.00017

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:8016

Mce/MlaD, and Permease MlaE

11 of 19

2.54

10.76

2.85e-24

CL:8017

Mce/MlaD, and Permease MlaE

8 of 10

2.68

8.39

1.84e-17

CL:8021

Mce/MlaD, and Sterol transport

5 of 5

2.78

5.12

2.21e-10

CL:8039

Phospholipid transport, and Sterol transport

3 of 5

2.56

2.4

3.38e-05

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map02010

ABC transporters

11 of 318

1.32

2.34

5.42e-13

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-9635465

Suppression of apoptosis

5 of 21

2.16

3.82

7.80e-09

MAP-9637690

Response of Mtb to phagocytosis

5 of 103

1.47

1.84

6.21e-06

MAP-9635486

Infection with Mycobacterium tuberculosis

5 of 258

1.07

0.98

0.00033

MAP-5663205

Infectious disease

5 of 259

1.07

0.98

0.00033

MAP-1643685

Disease

5 of 267

1.05

0.97

0.00033

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:1990351

Transporter complex

6 of 77

1.67

2.45

4.61e-07

GOCC:1990531

Phospholipid-translocating ATPase complex

2 of 2

2.78

1.69

0.00082

GOCC:0043190

ATP-binding cassette (ABC) transporter complex

4 of 63

1.58

1.44

0.00049

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02470

MlaD protein

5 of 12

2.4

3.91

1.98e-08

PF02405

Permease MlaE

4 of 4

2.78

3.75

1.07e-07

PF11887

Cholesterol uptake porter CUP1 of Mce4, putative

2 of 3

2.6

1.21

0.0062

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR024516

Mammalian cell entry, C-terminal

5 of 12

2.4

3.72

4.97e-08

IPR005693

Virulence factor Mce protein

5 of 12

2.4

3.72

4.97e-08

IPR003399

Mce/MlaD

5 of 12

2.4

3.72

4.97e-08

IPR030802

ABC transporter permease MalE

4 of 4

2.78

3.7

1.34e-07

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (14%) [HD]

Permalink

Network

Neighborhood

Experiments

Cooccurrence

Databases

Fusion

Textmining

Coexpression

© STRING Consortium 2024

Credits

Access

Info

About