node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Xcel_0051 | Xcel_1840 | Xcel_0051 | Xcel_1840 | PFAM: methylenetetrahydrofolate reductase; KEGG: acp:A2cp1_2862 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.937 |
Xcel_0051 | Xcel_1940 | Xcel_0051 | Xcel_1940 | PFAM: methylenetetrahydrofolate reductase; KEGG: acp:A2cp1_2862 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.999 |
Xcel_0051 | Xcel_2290 | Xcel_0051 | Xcel_2290 | PFAM: methylenetetrahydrofolate reductase; KEGG: acp:A2cp1_2862 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | PFAM: Cys/Met metabolism pyridoxal-phosphate- dependent protein; KEGG: rsq:Rsph17025_4330 hypothetical protein. | 0.732 |
Xcel_0051 | Xcel_2407 | Xcel_0051 | Xcel_2407 | PFAM: methylenetetrahydrofolate reductase; KEGG: acp:A2cp1_2862 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Hypothetical protein; KEGG: ank:AnaeK_0563 thermosensitive mutation transmembrane protein, SuhR. | 0.762 |
Xcel_0051 | Xcel_2638 | Xcel_0051 | Xcel_2638 | PFAM: methylenetetrahydrofolate reductase; KEGG: acp:A2cp1_2862 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Cystathionine gamma-synthase; PFAM: Cys/Met metabolism pyridoxal-phosphate- dependent protein; KEGG: afw:Anae109_3845 cystathionine gamma-lyase. | 0.732 |
Xcel_0051 | folD | Xcel_0051 | Xcel_0755 | PFAM: methylenetetrahydrofolate reductase; KEGG: acp:A2cp1_2862 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.937 |
Xcel_0051 | gcvT | Xcel_0051 | Xcel_0045 | PFAM: methylenetetrahydrofolate reductase; KEGG: acp:A2cp1_2862 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.929 |
Xcel_0051 | glyA | Xcel_0051 | Xcel_0754 | PFAM: methylenetetrahydrofolate reductase; KEGG: acp:A2cp1_2862 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.959 |
Xcel_0051 | metK | Xcel_0051 | Xcel_1718 | PFAM: methylenetetrahydrofolate reductase; KEGG: acp:A2cp1_2862 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.798 |
Xcel_0051 | thyA | Xcel_0051 | Xcel_2834 | PFAM: methylenetetrahydrofolate reductase; KEGG: acp:A2cp1_2862 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.921 |
Xcel_1840 | Xcel_0051 | Xcel_1840 | Xcel_0051 | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | PFAM: methylenetetrahydrofolate reductase; KEGG: acp:A2cp1_2862 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.937 |
Xcel_1840 | Xcel_1940 | Xcel_1840 | Xcel_1940 | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.985 |
Xcel_1840 | Xcel_2290 | Xcel_1840 | Xcel_2290 | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | PFAM: Cys/Met metabolism pyridoxal-phosphate- dependent protein; KEGG: rsq:Rsph17025_4330 hypothetical protein. | 0.960 |
Xcel_1840 | Xcel_2638 | Xcel_1840 | Xcel_2638 | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | Cystathionine gamma-synthase; PFAM: Cys/Met metabolism pyridoxal-phosphate- dependent protein; KEGG: afw:Anae109_3845 cystathionine gamma-lyase. | 0.960 |
Xcel_1840 | glyA | Xcel_1840 | Xcel_0754 | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.463 |
Xcel_1840 | metK | Xcel_1840 | Xcel_1718 | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.979 |
Xcel_1940 | Xcel_0051 | Xcel_1940 | Xcel_0051 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | PFAM: methylenetetrahydrofolate reductase; KEGG: acp:A2cp1_2862 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.999 |
Xcel_1940 | Xcel_1840 | Xcel_1940 | Xcel_1840 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.985 |
Xcel_1940 | Xcel_2290 | Xcel_1940 | Xcel_2290 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | PFAM: Cys/Met metabolism pyridoxal-phosphate- dependent protein; KEGG: rsq:Rsph17025_4330 hypothetical protein. | 0.971 |
Xcel_1940 | Xcel_2407 | Xcel_1940 | Xcel_2407 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Hypothetical protein; KEGG: ank:AnaeK_0563 thermosensitive mutation transmembrane protein, SuhR. | 0.759 |