node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Xcel_0229 | Xcel_0963 | Xcel_0229 | Xcel_0963 | Hypothetical protein. | PFAM: LmbE family protein; KEGG: GK21299 gene product from transcript GK21299- RA. | 0.774 |
Xcel_0229 | mca | Xcel_0229 | Xcel_2633 | Hypothetical protein. | Mycothiol conjugate amidase Mca; A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl-inositol) S- conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics; Belongs to the MshB deacetylase family. Mca subfamily. | 0.778 |
Xcel_0229 | mshA | Xcel_0229 | Xcel_2973 | Hypothetical protein. | UDP-N-acetylglucosamine; Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2-acetamido-2- deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway. | 0.610 |
Xcel_0229 | mshC | Xcel_0229 | Xcel_1479 | Hypothetical protein. | cysteine/1-D-myo-inosityl 2-amino-2-deoxy-alpha- D-glucopyranoside ligase; Catalyzes the ATP-dependent condensation of GlcN-Ins and L- cysteine to form L-Cys-GlcN-Ins; Belongs to the class-I aminoacyl-tRNA synthetase family. MshC subfamily. | 0.737 |
Xcel_0229 | mshD | Xcel_0229 | Xcel_0316 | Hypothetical protein. | Mycothiol biosynthesis acetyltransferase; Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol. | 0.794 |
Xcel_0300 | mshD | Xcel_0300 | Xcel_0316 | PFAM: phosphate transporter; KEGG: gme:Gmet_3131 phosphate transporter. | Mycothiol biosynthesis acetyltransferase; Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol. | 0.595 |
Xcel_0300 | ppk | Xcel_0300 | Xcel_0302 | PFAM: phosphate transporter; KEGG: gme:Gmet_3131 phosphate transporter. | Polyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Belongs to the polyphosphate kinase 1 (PPK1) family. | 0.510 |
Xcel_0317 | acsA | Xcel_0317 | Xcel_0318 | PFAM: protein of unknown function DUF1016; KEGG: apl:APL_1460 hypothetical protein. | acetate/CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.490 |
Xcel_0317 | mshD | Xcel_0317 | Xcel_0316 | PFAM: protein of unknown function DUF1016; KEGG: apl:APL_1460 hypothetical protein. | Mycothiol biosynthesis acetyltransferase; Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol. | 0.782 |
Xcel_0963 | Xcel_0229 | Xcel_0963 | Xcel_0229 | PFAM: LmbE family protein; KEGG: GK21299 gene product from transcript GK21299- RA. | Hypothetical protein. | 0.774 |
Xcel_0963 | mca | Xcel_0963 | Xcel_2633 | PFAM: LmbE family protein; KEGG: GK21299 gene product from transcript GK21299- RA. | Mycothiol conjugate amidase Mca; A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl-inositol) S- conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics; Belongs to the MshB deacetylase family. Mca subfamily. | 0.412 |
Xcel_0963 | mshA | Xcel_0963 | Xcel_2973 | PFAM: LmbE family protein; KEGG: GK21299 gene product from transcript GK21299- RA. | UDP-N-acetylglucosamine; Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2-acetamido-2- deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway. | 0.878 |
Xcel_0963 | mshC | Xcel_0963 | Xcel_1479 | PFAM: LmbE family protein; KEGG: GK21299 gene product from transcript GK21299- RA. | cysteine/1-D-myo-inosityl 2-amino-2-deoxy-alpha- D-glucopyranoside ligase; Catalyzes the ATP-dependent condensation of GlcN-Ins and L- cysteine to form L-Cys-GlcN-Ins; Belongs to the class-I aminoacyl-tRNA synthetase family. MshC subfamily. | 0.834 |
Xcel_0963 | mshD | Xcel_0963 | Xcel_0316 | PFAM: LmbE family protein; KEGG: GK21299 gene product from transcript GK21299- RA. | Mycothiol biosynthesis acetyltransferase; Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol. | 0.848 |
Xcel_3035 | mshD | Xcel_3035 | Xcel_0316 | Putative two component transcriptional regulator, winged helix family; PFAM: transcriptional regulator domain protein; KEGG: bsu:BSU03750 hypothetical protein. | Mycothiol biosynthesis acetyltransferase; Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol. | 0.614 |
acsA | Xcel_0317 | Xcel_0318 | Xcel_0317 | acetate/CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | PFAM: protein of unknown function DUF1016; KEGG: apl:APL_1460 hypothetical protein. | 0.490 |
acsA | mshD | Xcel_0318 | Xcel_0316 | acetate/CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | Mycothiol biosynthesis acetyltransferase; Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol. | 0.556 |
mca | Xcel_0229 | Xcel_2633 | Xcel_0229 | Mycothiol conjugate amidase Mca; A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl-inositol) S- conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics; Belongs to the MshB deacetylase family. Mca subfamily. | Hypothetical protein. | 0.778 |
mca | Xcel_0963 | Xcel_2633 | Xcel_0963 | Mycothiol conjugate amidase Mca; A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl-inositol) S- conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics; Belongs to the MshB deacetylase family. Mca subfamily. | PFAM: LmbE family protein; KEGG: GK21299 gene product from transcript GK21299- RA. | 0.412 |
mca | mshA | Xcel_2633 | Xcel_2973 | Mycothiol conjugate amidase Mca; A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl-inositol) S- conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics; Belongs to the MshB deacetylase family. Mca subfamily. | UDP-N-acetylglucosamine; Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2-acetamido-2- deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway. | 0.777 |