STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
Xcel_2233TIGRFAM: DNA polymerase LigD, polymerase domain protein; DNA ligase D, 3'-phosphoesterase domain protein; DNA polymerase LigD, ligase domain protein; PFAM: ATP dependent DNA ligase; DNA primase small subunit; ATP dependent DNA ligase domain protein; KEGG: mpt:Mpe_B0011 ATP-dependent DNA ligase. (858 aa)    
Predicted Functional Partners:
ku
Ku protein; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family.
 
  
 0.983
Xcel_0002
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
   
 0.925
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 0.916
Xcel_3155
TIGRFAM: exodeoxyribonuclease III Xth; PFAM: Endonuclease/exonuclease/phosphatase; KEGG: mxa:MXAN_5178 exodeoxyribonuclease III.
 
 
 0.891
Xcel_3280
PFAM: 5'-3' exonuclease; SMART: 5'-3' exonuclease; Helix-hairpin-helix domain protein class 2; KEGG: pca:Pcar_2864 DNA polymerase I.
 
 0.728
Xcel_2642
KEGG: acp:A2cp1_4312 DNA ligase I, ATP-dependent Dnl1; TIGRFAM: DNA ligase I, ATP-dependent Dnl1; PFAM: ATP dependent DNA ligase; ATP dependent DNA ligase domain protein; DNA ligase domain protein; Belongs to the ATP-dependent DNA ligase family.
 
   
 0.675
Xcel_0757
TIGRFAM: exodeoxyribonuclease III Xth; PFAM: Endonuclease/exonuclease/phosphatase; KEGG: nma:NMA0348 putative nuclease.
  
 
 0.643
Xcel_1096
KEGG: sml:Smlt0110 putative viral-like DNA topoisomerase.
 
 
 
 0.640
Xcel_2232
PFAM: RelA/SpoT domain protein; KEGG: bha:BH1885 hypothetical protein.
       0.571
recA
recA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
 
 0.565
Your Current Organism:
Xylanimonas cellulosilytica
NCBI taxonomy Id: 446471
Other names: X. cellulosilytica DSM 15894, Xylanimonas cellulosilytica DSM 15894, Xylanimonas cellulosilytica str. DSM 15894, Xylanimonas cellulosilytica strain DSM 15894
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