| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Xcel_2830 | Xcel_2831 | Xcel_2830 | Xcel_2831 | Hypothetical protein; KEGG: bur:Bcep18194_B0758 outer membrane autotransporter barrel. | Hypothetical protein. | 0.447 |
| Xcel_2830 | Xcel_2832 | Xcel_2830 | Xcel_2832 | Hypothetical protein; KEGG: bur:Bcep18194_B0758 outer membrane autotransporter barrel. | TIGRFAM: peptidase S26B, signal peptidase; PFAM: peptidase S24 and S26 domain protein; KEGG: bcb:BCB4264_A1329 signal peptidase I. | 0.447 |
| Xcel_2831 | Xcel_2830 | Xcel_2831 | Xcel_2830 | Hypothetical protein. | Hypothetical protein; KEGG: bur:Bcep18194_B0758 outer membrane autotransporter barrel. | 0.447 |
| Xcel_2831 | Xcel_2832 | Xcel_2831 | Xcel_2832 | Hypothetical protein. | TIGRFAM: peptidase S26B, signal peptidase; PFAM: peptidase S24 and S26 domain protein; KEGG: bcb:BCB4264_A1329 signal peptidase I. | 0.777 |
| Xcel_2831 | Xcel_2833 | Xcel_2831 | Xcel_2833 | Hypothetical protein. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.415 |
| Xcel_2831 | thyA | Xcel_2831 | Xcel_2834 | Hypothetical protein. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.415 |
| Xcel_2832 | Xcel_2830 | Xcel_2832 | Xcel_2830 | TIGRFAM: peptidase S26B, signal peptidase; PFAM: peptidase S24 and S26 domain protein; KEGG: bcb:BCB4264_A1329 signal peptidase I. | Hypothetical protein; KEGG: bur:Bcep18194_B0758 outer membrane autotransporter barrel. | 0.447 |
| Xcel_2832 | Xcel_2831 | Xcel_2832 | Xcel_2831 | TIGRFAM: peptidase S26B, signal peptidase; PFAM: peptidase S24 and S26 domain protein; KEGG: bcb:BCB4264_A1329 signal peptidase I. | Hypothetical protein. | 0.777 |
| Xcel_2832 | Xcel_2833 | Xcel_2832 | Xcel_2833 | TIGRFAM: peptidase S26B, signal peptidase; PFAM: peptidase S24 and S26 domain protein; KEGG: bcb:BCB4264_A1329 signal peptidase I. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.436 |
| Xcel_2832 | thyA | Xcel_2832 | Xcel_2834 | TIGRFAM: peptidase S26B, signal peptidase; PFAM: peptidase S24 and S26 domain protein; KEGG: bcb:BCB4264_A1329 signal peptidase I. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.437 |
| Xcel_2833 | Xcel_2831 | Xcel_2833 | Xcel_2831 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Hypothetical protein. | 0.415 |
| Xcel_2833 | Xcel_2832 | Xcel_2833 | Xcel_2832 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | TIGRFAM: peptidase S26B, signal peptidase; PFAM: peptidase S24 and S26 domain protein; KEGG: bcb:BCB4264_A1329 signal peptidase I. | 0.436 |
| Xcel_2833 | thyA | Xcel_2833 | Xcel_2834 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.999 |
| thyA | Xcel_2831 | Xcel_2834 | Xcel_2831 | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | Hypothetical protein. | 0.415 |
| thyA | Xcel_2832 | Xcel_2834 | Xcel_2832 | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | TIGRFAM: peptidase S26B, signal peptidase; PFAM: peptidase S24 and S26 domain protein; KEGG: bcb:BCB4264_A1329 signal peptidase I. | 0.437 |
| thyA | Xcel_2833 | Xcel_2834 | Xcel_2833 | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.999 |