Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
glnEGlutamine-synthetase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transducti [...] (1021 aa)    
Predicted Functional Partners:
ALU39873.1
Glutamine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.899
ALU39875.1
Glutamine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.796
rbpA
Hypothetical protein; Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters. Belongs to the RNA polymerase-binding protein RbpA family.
  
     0.663
ALU40402.1
Transcriptional regulator; Indirectly regulates nitrogen metabolism; at high nitrogen levels P-II prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 
 0.661
ALU38940.1
dUTPase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.658
ALU39084.1
dUTPase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.653
ALU38567.1
dUTPase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.646
ALU39897.1
dUTPase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.645
ALU39675.1
dUTPase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.638
ALU39840.1
Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.636
Your Current Organism:
Kocuria flava
NCBI taxonomy Id: 446860
Other names: CCTCC AB 206106, JCM 15621, KCTC 19306, Kocuria flava Zhou et al. 2008, Kocuria sp. HO-9041, strain HO-9041
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