STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SUMOSmall ubiquitin-like protein. (98 aa)    
Predicted Functional Partners:
ubc9
Sumo-conjugating enzyme ubc9; Accepts the ubiquitin-like protein sumo from the E1 complex and catalyzes its covalent attachment to other proteins with the help of an E3 ligase.
   
 0.996
DDB_G0287153
UBIQUITIN_CONJUGAT_2 domain-containing protein.
   
 0.982
uba2
SUMO-activating enzyme subunit 2; The dimeric enzyme acts as an E1 ligase for sumo. It mediates ATP-dependent activation of sumo and formation of a thioester with a conserved cysteine residue on sae2 (By similarity); Belongs to the ubiquitin-activating E1 family.
   
 0.981
sae1
SUMO-activating enzyme subunit 1; The dimeric enzyme acts as an E1 ligase for sumo. It mediates ATP-dependent activation of sumo and formation of a thioester with a conserved cysteine residue on sae2 (By similarity); Belongs to the ubiquitin-activating E1 family.
   
 0.972
DDB0184304
ULP_PROTEASE domain-containing protein.
   
 0.937
smc5
Structural maintenance of chromosome protein.
   
 0.936
pcna
Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.
   
 0.925
nedd8
NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control, embryogenesis and neurogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex ube1c/uba3- ula1 and linkage to the E2 enzyme ube2m/ubc12. Attachment of nedd8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (By similarity).
   
 
 0.894
DDB0191980
ULP_PROTEASE domain-containing protein.
   
 
 0.820
DDB0219453
ULP_PROTEASE domain-containing protein.
   
 
 0.820
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: D. discoideum
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