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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DG1110Developmental protein DG1110. (544 aa)    
Predicted Functional Partners:
DDB_G0281309
Uncharacterized protein.
      
 0.450
IptC-1
Uncharacterized protein; Belongs to the IPP transferase family.
      
 0.450
aprt
Probable adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
   
  
 0.450
IptB
C2H2-type domain-containing protein.
      
 0.446
rdeA
Phosphorelay intermediate protein rdeA; Phosphorelay protein that supplies phosphate to regA or accepts phosphate from regA; depending on the relative concentration of the phosphodonor proteins. In vitro, acts as a substrate for cheA (bacterial kinase). Plays a role in the development. ypd1 (yeast) can complement rdeA defect.
      
 0.446
acgA
Adenylate cyclase, germination specific; Has a large extracellular domain which may be involved in the recognition of an extracellular signal present during germination, leading to activation or inhibition of cAMP synthesis by the cytoplasmic domain.
      
 0.444
cdk5rap1
CDK5RAP1-like protein; Probable regulator of CDK5 activity; Belongs to the methylthiotransferase family. MiaB subfamily.
      
 0.444
dhkB
Hybrid signal transduction histidine kinase B; Acts in the cytokinin signal transduction pathway that regulates spore germination. Required for the maintenance of spore dormancy. Does not appear to act as a cytokinin receptor. Probably undergoes ATP-dependent autophosphorylation at a conserved histidine residue in the kinase core, which is followed by transfer of the phosphoryl group to a conserved aspartate residue in the receiver domain.
      
 0.441
dhkA
Hybrid signal transduction histidine kinase A; Acts as a receptor histidine kinase for the cytokinin SDF-2 in a signal transduction pathway that regulates prestalk gene expression and controls terminal differentiation of prespore cells. Binding of SDF-2 to this protein inhibits phosphorelay and induces rapid sporulation. This protein undergoes an ATP-dependent autophosphorylation at a conserved histidine residue in the kinase core, and a phosphoryl group is then transferred to a conserved aspartate residue in the receiver domain.
   
  
 0.408
adk
Adenosine kinase; ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.
      
 0.400
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: D. discoideum
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