STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mlcEMyosin, essential light chain. (150 aa)    
Predicted Functional Partners:
mlcR
Myosin regulatory light chain.
  
 
0.929
mhcA
Myosin-2 heavy chain; Myosin is a protein that binds to actin and has ATPase activity that is activated by actin; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
   
 0.903
pakB
Serine/threonine-protein kinase pakB; Regulator of the myosin I component of the cytoskeleton: required for regulation of cytokinesis, phagocytosis and pinocytosis. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
    
 0.767
roco5
Probable serine/threonine-protein kinase roco5; May act as a serine/threonine-protein kinase and guanine- nucleotide releasing factor.
   
 
 0.761
roco8
Probable serine/threonine-protein kinase roco8; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. ROCO subfamily.
   
 
 0.761
roco6
Probable serine/threonine-protein kinase roco6; May act as a serine/threonine-protein kinase and guanine- nucleotide releasing factor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. ROCO subfamily.
   
 
 0.761
roco11
Probable serine/threonine-protein kinase roco11; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. ROCO subfamily.
   
 
 0.761
qkgA-1
Probable serine/threonine-protein kinase qkgA; Involved in growth, and during development, in aggregation.
   
 
 0.761
iplA
Inositol 1,4,5-trisphosphate receptor-like protein A; May be a receptor for inositol 1,4,5 trisphosphate which governs calcium fluxes from the endoplasmic reticulum stores into the cytosol. May be involved in autophagic cell death.
    
 
 0.735
canA
Serine/threonine-protein phosphatase 2B catalytic subunit; Catalytic subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. Belongs to the PPP phosphatase family. PP-2B subfamily.
    
 
 0.729
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: D. discoideum
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