STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cdk1Cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. (296 aa)    
Predicted Functional Partners:
cycB
G2/mitotic-specific cyclin-B; Essential for the control of the cell cycle at the G2/M (mitosis) transition.
 
 
 0.980
DDB_G0294575
Ankyrin repeat-containing protein.
    
 
 0.968
DDB0203462
Uncharacterized protein.
    
 
 0.968
DDB0217047
Uncharacterized protein.
    
 
 0.968
cycA
Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.
   
 0.932
CycD
Uncharacterized protein; Belongs to the cyclin family.
   
 0.932
DDB0203551
AAA_16 domain-containing protein.
   
 0.915
cdc25
M-phase inducer phosphatase; Tyrosine protein phosphatase which may function as a dosage- dependent inducer in mitotic control; Belongs to the MPI phosphatase family.
   
 0.907
DDB_G0277539
Probable protein kinase DDB_G0277539; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.
  
0.902
cdc20
Anaphase-promoting complex subunit cdc20; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle; Belongs to the WD repeat CDC20/Fizzy family.
   
 
 0.885
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: D. discoideum
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.