STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
glpDGlycogen phosphorylase 2; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (993 aa)    
Predicted Functional Partners:
pgmA
Phosphoglucomutase-1; This enzyme participates in both the breakdown and synthesis of glucose; Belongs to the phosphohexose mutase family.
  
 
 0.996
Agl
Uncharacterized protein.
  
 0.996
glgB
1,4-alpha-glucan-branching enzyme.
 
 0.995
uppA
UTP--glucose-1-phosphate uridylyltransferase 1; Plays a central role as a glucosyl donor in cellular metabolic pathways. During development the lack of the enzyme activity leads to cell death and lysis. Strains which lack UDPG pyrophosphorylase accomplish early developmental events but are unable to culminate. The enzyme affects the growth rate of the cells but is not essential for growth; Belongs to the UDPGP type 1 family.
   
 
 0.992
DDB0185931
Uncharacterized protein.
 
 
 0.991
pgmB
Probable phosphoglucomutase-2; This enzyme participates in both the breakdown and synthesis of glucose; Belongs to the phosphohexose mutase family.
  
 
 0.967
ugpB
UTP--glucose-1-phosphate uridylyltransferase 2; Plays a central role as a glucosyl donor in cellular metabolic pathways; Belongs to the UDPGP type 1 family.
   
 
 0.958
amyA
Putative alpha-amylase.
  
 0.956
glcS
Glycogen [starch] synthase; Transfers the glycosyl residue from UDPG to the non-reducing end of alpha-1,4-glucan.
  
 
 0.921
DDB0216797
Nudix hydrolase domain-containing protein.
    
 0.906
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: D. discoideum
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.