STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
qpctGlutaminyl-peptide cyclotransferase; Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N- terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also catalyzes N-terminal pyroglutamate formation (By similarity); Belongs to the glutaminyl-peptide cyclotransferase family. (360 aa)    
Predicted Functional Partners:
DDB0204972
Uncharacterized protein.
   
  
 0.523
ufm1
Ubiquitin-fold modifier 1; Ubiquitin-like modifier which can be covalently attached to substrate proteins as a monomer or a lysine-linked polymer in a post- translational process called ufmylation. Ufmylation on lysine residues of proteins may play a crucial role in a number of cellular processes. Belongs to the UFM1 family.
   
  
 0.498
DDB0203515
HIT-type domain-containing protein.
   
  
 0.490
pykA
Pyridoxal kinase; Required for synthesis of pyridoxal-5-phosphate from vitamin B6.
   
 
  0.490
DDB0167887
Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.
     
 0.480
lkhA
Leucine aminopeptidase; Aminopeptidase that preferentially cleaves di- and tripeptides. Also has low epoxide hydrolase activity (in vitro). Can hydrolyze the epoxide leukotriene LTA(4) but it forms preferentially 5,6-dihydroxy-7,9,11,14-eicosatetraenoic acid rather than the cytokine leukotriene B(4) as the product compared to the homologous mammalian enzyme (in vitro).
     
 0.420
ctsD
Cathepsin D; Protease that may act during cell growth and/or development; Belongs to the peptidase A1 family.
   
 
  0.414
DocC
DHR-2 domain-containing protein; Belongs to the DOCK family.
   
 
  0.412
armc8
Armadillo repeat-containing protein.
   
 
  0.410
ypel
Protein yippee-like; Belongs to the yippee family.
   
 
  0.410
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: D. discoideum
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